Abstract
Gene expression is a central phenomenon in all organisms. The first step in the expression of a gene is the transcription of the DNA to generate a messenger RNA, which is subsequently translated to a protein. In response to cellular and environmental cues regulatory proteins, known as transcriptional activators or repressors, either enhance or inhibit transcription of specific genes. Here, a summary of our current understanding of this initial step in gene expression is presented, along with the recent advances in creating synthetic analogs of regulatory transcription factors. The study of transcriptional regulation of an individual gene as well as that of all genes in the genome is now accessible to rational chemical intervention. The current challenges in the design of small-molecule transcription factors and their potential role in generating novel transcription-based therapeutics are also discussed.
Keywords: Gene Expression, Synthetic Transcriptional, EXPRESSION, General Transcription, RNA polymerase, Holoenzyme, CHROMATIN, ACTIVATORS, DNA BINDING MODULES, GENOME, Major Groove Targeting
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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