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Review Article

靶向磷酸二酯酶的多功能配体作为阿尔茨海默氏病症状和疾病改善治疗的未来策略

卷 27, 期 32, 2020

页: [5351 - 5373] 页: 23

弟呕挨: 10.2174/0929867326666190620095623

价格: $65

摘要

阿尔茨海默氏病（AD）是一种慢性神经退行性疾病，其特征是认知障碍，例如记忆力丧失，语言能力下降和迷失方向，影响全球4600万人。 AD患者还患有痴呆症的行为和心理症状，这会降低其生活质量并导致过早死亡。目前可用的药物可减轻症状，但不能减轻病理特征（老年斑和神经原纤维缠结）和神经炎症，这两者都是痴呆症的组成部分。大量证据表明，环3''，5''-单磷酸腺苷（cAMP）和环3''，5''-单磷酸鸟苷（cGMP）的信号通路受损可能有助于AD的发展和进程。另外，发现磷酸二酯酶（PDE）抑制剂通常被称为cAMP和/或cGMP调节剂，与tau的磷酸化有关。淀粉样β的聚集；神经发炎;以及对认知，情绪和情感处理的调节。这篇综述的目的是更新有关靶向PDE的新型多功能配体的开发的最新报道，所述PDE作为AD的症状和疾病缓解疗法的潜在药物。这篇综述收集了代表性多功能配体的化学结构，体外和体内药理实验的结果以及有关这些化合物用于AD全面治疗的潜在效用的最新见解。最后，计算并讨论了代表性化合物的可塑性的多参数预测。

关键词: 阿尔茨海默氏病，痴呆的行为和心理症状，认知障碍，神经炎症，病理特征，磷酸二酯酶，PDE抑制剂，多功能配体。

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