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Review Article

抗布氏锥虫药物发现中的类黄酮衍生的特权支架

卷 20, 期 12, 2019

页: [1295 - 1314] 页: 20

弟呕挨: 10.2174/1389450120666190618114857

价格: $65

摘要

背景：人类非洲锥虫病（HAT），也称为昏睡病，是世界卫生组织列出的20种被忽视的热带病之一，如果不及时治疗会导致死亡。这种疾病是由冈比亚布氏锥虫（格鲁吉斯是一种慢性形式的非洲西部和中部）以及布鲁氏罗氏体（T. brucei rhodesiense）引起的，该种是非洲东部和南部的一种急性形式。许多报道都强调了黄酮类化合物对T. brucei的有效性。目的：本综述总结了目前使用黄酮类化合物作为潜在治疗HAT的先导化合物的观点和观点。 方法：通过参考教科书和科学数据库（SciFinder，PubMed，Science Direct，Wiley，ACS，SciELO，Google Scholar，Springer等）从开始到2月，对天然存在的和合成的抗T布鲁氏菌黄酮类进行了文献检索。 2019。 结果：据报道，从植物和物种的不同部分分离的黄酮类化合物对T.brucei表现出中到高的体外抗锥体体活性。此外，合成黄酮类化合物显示出抗T.布鲁西活动。生物活性类黄酮与布氏锥虫蛋白靶标的分子相互作用显示出有希望的结果。 结论：根据体外抗T brucei研究，有证据表明黄酮类化合物可能是潜在治疗HAT的先导化合物。然而，需要毒理学研究以及体外活性类黄酮的作用机制来支持它们作为治疗HAT的潜在线索的用途。

关键词: 人类非洲锥虫病，黄酮类化合物，分子靶点，药物发现，被忽视的热带病，锥虫（Trypanosoma brucei gambiense）。

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