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Review Article

MDSC与移植免疫耐受的相关性：细胞因子，通路和细胞间相互作用

卷 19, 期 2, 2019

页: [81 - 92] 页: 12

弟呕挨: 10.2174/1566523219666190618093707

价格: $65

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摘要

MDSCs在诱导免疫耐受中起重要作用。 细胞因子和趋化因子（GM-CSF，IL-6）通过iNOS，精氨酸酶和PD-L1促进MDSCs的扩增，积累和MDSCs的功能。 通过JAK / STAT，mTOR和Raf / MEK / ERK信号传导途径募集和调节MDSC。 MDSCs的免疫抑制功能通过Tregs介导的途径及其对免疫细胞的直接抑制来实现。 所有这些都有助于移植中MDSC相关的免疫耐受。 MDSCs在延长移植物存活率和减少排斥反应方面具有巨大的潜力，并且还引入了许多值得进一步研究的因素。

关键词: 髓源性抑制细胞，免疫耐受，移植，GM-CSF，CXCR2，JAK / STAT。

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图形摘要

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