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Research Article

同型半胱氨酸血清水平作为肝细胞癌门静脉血栓形成的预后标志物

卷 19, 期 7, 2019

页: [532 - 538] 页: 7

弟呕挨: 10.2174/1566524019666190610120416

价格: $65

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摘要

背景：门静脉血栓形成（PVT）是终末期肝细胞癌（HCC）的常见并发症。 我们的研究目的是评估同型半胱氨酸（Hcy）在患有PVT的HCC患者中的作用。 Hcy是一种硫氨基酸，参与两种途径，反式硫化和再甲基化，涉及维生素B6，B12和叶酸。 方法：我们招募了54例HCC和PVT患者，60例HCC患者和无PVT患者以及60例对照者。 我们测量了血清Hcy，叶酸，维生素B6和B12的水平。 结果：HCC患者PVT与无PVT的HCC患者之间的比较显示，Hcy的平均值为6.4 nmol / L(p <0.0073)，LDL胆固醇为4.8 mg / dl(p <0.0079)，维生素B6为4.6nmol / L(p = 0.0544)较低，维生素B12较低，为22.1 pg / ml(p = 0.0001)。 结论：高血清Hcy水平是一般人群中确定的血栓形成危险因素。 我们发现，与没有PVT和对照的HCC患者相比，PVT患者的Hcy水平显着升高。

关键词: 同型半胱氨酸，维生素B12，维生素B6，叶酸，肝细胞癌，门静脉血栓形成，表观遗传。

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