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Review Article

实体器官移植中的细胞疗法

卷 19, 期 2, 2019

页: [71 - 80] 页: 10

弟呕挨: 10.2174/1566523219666190603103840

价格: $65

摘要

移植是治疗终末期器官衰竭的唯一方法。 目前的免疫抑制药物有两个主要限制：1）非抗原特异性，其增加癌症和感染疾病的风险，2）慢性毒性。 细胞疗法似乎是一种创新且有前景的策略，可以最大限度地减少免疫抑制在移植中的使用并改善长期移植物存活。 临床前研究已显示使用各种抑制细胞的功效和安全性，例如调节性T细胞，调节性B细胞和致耐受性树突细胞。 最近在实体器官移植中使用基于细胞的疗法的临床试验也证实了提高疗效的希望。 在本综述中，我们将简要介绍排斥过程，目前的免疫抑制药物以及调节细胞在移植中的潜在治疗用途。

关键词: 细胞疗法，免疫抑制，实体器官移植，慢性毒性，抗原特异性，DAMP。

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图形摘要

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