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Review Article

放射化学：眼科药物发现中的有用工具

卷 27, 期 4, 2020

页: [501 - 522] 页: 22

弟呕挨: 10.2174/0929867326666190530122032

价格: $65

摘要

正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）是超灵敏，完全平移和微创核成像技术，能够追踪给药后正电子（PET）或伽马（SPECT）发射体标记的分子的时空分布进入生物体。除了在临床诊断中的作用外，PET和SPECT在药物开发过程中也起着越来越重要的作用，在评估新化学实体的药代动力学特性以及概念验证，机理验证和药物验证中都发挥着越来越重要的作用。功效研究。但是，它们几乎没有用于眼科药物。在本文中，简要讨论了核成像和放射化学的基础知识，并介绍和讨论了文献中报道的在眼科药物开发中使用这些成像方式的几个例子。最后，在纯粹的理论研究中，提出了一些可用于制备所选眼科药物的标记策略，并预测了核成像在眼科中的潜在应用。

关键词: 正电子发射断层扫描（PET），单光子发射计算机断层扫描（SPECT），放射化学，核成像，眼科，药物开发。

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