Abstract
Background: A lot of people are facing some health-related problems in day to day life. The conventional drug delivery is not able to cure it alone, moreover, some drugs have poor solubility, low half-life and show lesser bioavailability. It is necessary to conduct research on carrier-based nanoparticulate drug delivery, this is an alternative approach to alter/eliminate the problem of conventional dosing for better effectiveness, patient compliance, and effective drug targeting.
Objective: To develop a carrier-based nanoparticulate drug delivery system for the elimination of problems associated with conventional dosage form.
Methods: In this review, different problems associated with conventional dosage form as well as potential advantages of the nanoparticulate delivery systems have been discussed. We also discussed their different route for administration such as oral, intranasal, ocular, transdermal, vaginal etc. for effective drug targeting. It has been found that different nanocarriers based drug delivery have been able to enhance the bioavailability, solubility, minimized adverse effect as well as effective in Gene delivery also. Ionic gelation, Solvent evaporation, emulsification, homogenization, lyophilisation, etc. are techniques used for their development.
Conclusion: The carrier-based drug delivery technique act as an effective drug delivery system for the treatment of various diseases/disorders as well as provides better efficiency, bioavailability and improve patient compliance.
Keywords: Nanocarriers, nanoparticles, bioavailability, application, sustained release, drug delivery.
Graphical Abstract
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