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Systematic Review Article

植物衍生天然产物的抗炎特性–系统评价

卷 26, 期 24, 2019

页: [4506 - 4536] 页: 31

弟呕挨: 10.2174/0929867325666190523123357

价格: $65

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摘要

传统上，天然药物是作为植物提取物施用的，它是由分子混合物组成的。 该混合物中的单个分子物质可能会或可能不会对整体药物作用做出贡献，有些甚至会阻碍其他药物的有益活性。 为了更好地控制治疗效果，过去几十年来进行了表征特定分子并描述其个别活性的研究。 这些研究似乎强调了天然产物作为抗氧化剂和消炎剂特别有效。 在本系统综述中，我们旨在鉴定有效的抗炎天然产物，并将其功效与其化学结构和理化性质相关联。 为了鉴定这些化合物，我们进行了全面的文献搜索以找到那些研究，其中使用剂量反应说明和阳性对照参考化合物对观察到的活性进行基准测试。 在分析的论文中，最初选择的研究中有7％满足了这些要求，并进行了进一步分析。 该分析表明，大多数选定的天然产物确实似乎具有抗炎活性，尤其是抗氧化特性。 此外，在所有测试的测定中，有14％的天然产物优于其余的天然产物，并且作为新的抗炎药是有吸引力的候选物。

关键词: 天然产物，抗炎活性，结构活性关系，理化性质，生物学测定，治疗效果。

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