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Review Article

急性髓系白血病治疗中的免疫脂质体：可能的靶点和障碍综述

卷 26, 期 28, 2019

页: [5278 - 5292] 页: 15

弟呕挨: 10.2174/0929867326666190517114450

open access plus

摘要

急性髓细胞性白血病（AML）是造血干细胞（HSC）的肿瘤转化，复发性疾病是治疗中的主要挑战。尽管医学领域取得了技术进步，并且我们对AML的发病机理有了更深入的了解，但自1973年以来，“ 7 + 3”阿糖胞苷和柔红霉素的初始治疗仍基本保持不变。AML是一种老年人疾病，其发病率增加。患者组不允许充分使用治疗，耐药性复发很普遍。纳米载体是一种药物输送系统，可用于将药物输送到骨髓并靶向白血病干细胞（LSC），与免费药物替代品相比，副作用较小。纳米载体也可用于促进药物的运输，否则由于毒性和疗效差而无法在临床上使用。脂质体是可以用作专用药物递送系统的一种纳米载体，其也可以在表面具有活性配体以便与靶细胞或组织上的抗原相互作用。除了使用小分子外，还可以将抗体附着于脂质体表面，从而产生所谓的免疫脂质体。通过使用免疫脂质体作为药物递送系统，可以最小化化疗药物对健康器官造成的毒性副作用，同时将药物引向剩余的AML母细胞和干细胞。本文旨在探讨在AML治疗中使用免疫脂质体作为药物载体的可能性。重点将放在AML细胞，白血病干细胞以及与AML治疗相关的骨髓成分上的可能靶分子上。此外，将讨论免疫脂质体用于AML治疗必须满足的一些条件和预防措施。

关键词: 急性髓系白血病、脂质体、抗体、免疫脂质体、骨髓、制药、生产。

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