Generic placeholder image

Current Computer-Aided Drug Design

Editor-in-Chief

ISSN (Print): 1573-4099
ISSN (Online): 1875-6697

Research Article

Identification of Novel Phyto-chemicals from Ocimum basilicum for the Treatment of Parkinson’s Disease using In Silico Approach

Author(s): Nageen Mubashir, Rida Fatima and Sadaf Naeem*

Volume 16, Issue 4, 2020

Page: [420 - 434] Pages: 15

DOI: 10.2174/1573409915666190503113617

Price: $65

Abstract

Background: Parkinson’s disease is characterized by decreased level of dopaminergic neurotransmitters and this decrease is due to the degradation of dopamine by protein Monoamine Oxidase B (MAO-B). In order to treat Parkinson’s disease, MAO-B should be inhibited.

Objective: To find out the novel phytochemicals from plant Ocimum basilicum that can inhibit MAO-B by using the in silico methods.

Methods: The data of chemical constituents from plant Ocimum basilicum was collected and inhibitory activity of these phytochemicals was then predicted by using the Structure-Based (SB) and Ligand-Based Virtual Screening (LBVS) methods. Molecular docking, one of the common Structure-Based Virtual Screening method, has been used during this search. Traditionally, molecular docking is used to predict the orientation and binding affinity of the ligand within the active site of the protein. Molegro Virtual Docker (MVD) software has been used for this purpose. On the other hand, Random Forest Model, one of the LBVS method, has also been used to predict the activity of these chemical constituents of Ocimum basilicum against the MAO-B.

Results: During the docking studies, all the 108 compounds found in Ocimum basilicum were docked within the active site of MAO-B (PDB code: 4A79) out of which, 57 compounds successfully formed the hydrogen bond with tyr 435, a crucial amino acid for the biological activity of the enzyme. Rutin (-182.976 Kcal/mol), Luteolin (-163.171 Kcal/mol), Eriodictyol-7-O-glucoside (- 160.13 Kcal/mol), Rosmarinic acid (-133.484 Kcal/mol) and Isoquercitrin (-131.493 Kcal/mol) are among the top hits with the highest MolDock score along with hydrogen interaction with tyr 435. Using the RF model, ten compounds out of 108 chemical constituent of Ocimum basilicum were predicted to be active, Apigenin (1.0), Eriodictyol (1.0), Orientin (0.876), Kaempferol (0.8536), Luteolin (0.813953) and Rosmarinic-Acid (0.7738095) are predicted to be most active with the highest RF score.

Conclusion: The comparison of the two screening methods show that the ten compounds that were predicted to be active by the RF model, are also found in top hits of docking studies with the highest score. The top hits obtained during this study are predicted to be the inhibitor of MAO-B, thus, could be used further for the development of drugs for the treatment of Parkinson’s disease (PD).

Keywords: Parkinson's disease, Monoamine Oxidase B, Ocimum basilicum, in silico methods, molecular docking, random forest model.

Graphical Abstract

[1]
Singer, T.P. Perspectives in MAO: past, present, and future. A review. J. Neural Transm. Suppl., 1987, 23, 1-23.
[http://dx.doi.org/10.1007/978-3-7091-8901-6_1] [PMID: 3295113]
[2]
Waldmeier, P.C. Amine oxidases and their endogenous substrates (with special reference to monoamine oxidase and the brain). J. Neural Transm. Suppl., 1987, 23, 55-72.
[http://dx.doi.org/10.1007/978-3-7091-8901-6_4] [PMID: 3108453]
[3]
Kosenko, E.; Kaminsky, Y.; Kaminsky, A.; Valencia, M.; Lee, L.; Hermenegildo, C.; Felipo, V. Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic. Res., 1997, 27(6), 637-644.
[http://dx.doi.org/10.3109/10715769709097867] [PMID: 9455699]
[4]
Danielczyk, W.; Streifler, M.; Konradi, C.; Riederer, P.; Moll, G. Platelet MAO-B activity and the psychopathology of Parkinson’s disease, senile dementia and multi-infarct dementia. Acta Psychiatr. Scand., 1988, 78(6), 730-736.
[http://dx.doi.org/10.1111/j.1600-0447.1988.tb06412.x] [PMID: 3223331]
[5]
Grünblatt, E.; Schlösser, R.; Fischer, P.; Fischer, M.O.; Li, J.; Koutsilieri, E.; Wichart, I.; Sterba, N.; Rujescu, D.; Möller, H.J.; Adamcyk, W.; Dittrich, B.; Müller, F.; Oberegger, K.; Gatterer, G.; Jellinger, K.J.; Mostafaie, N.; Jungwirth, S.; Huber, K.; Tragl, K.H.; Danielczyk, W.; Riederer, P. Oxidative stress related markers in the “VITA” and the centenarian projects. Neurobiol. Aging, 2005, 26(4), 429-438.
[http://dx.doi.org/10.1016/j.neurobiolaging.2004.06.001] [PMID: 15653171]
[6]
Robakis, D.; Fahn, S. Defining the role of the monoamine oxidase-b inhibitors for parkinson’s disease. CNS Drugs, 2015, 29(6), 433-441.
[http://dx.doi.org/10.1007/s40263-015-0249-8] [PMID: 26164425]
[7]
Wang, Z.; Wu, J.; Yang, X.; Cai, P.; Liu, Q.; Wang, K.D.G.; Kong, L.; Wang, X. Neuroprotective effects of benzyloxy substituted small molecule monoamine oxidase B inhibitors in Parkinson’s disease. Bioorg. Med. Chem., 2016, 24(22), 5929-5940.
[http://dx.doi.org/10.1016/j.bmc.2016.09.050] [PMID: 27692996]
[8]
Ilgın, S.; Osmaniye, D.; Levent, S.; Sağlık, B.N.; Acar Çevik, U.; Çavuşoğlu, B.K.; Özkay, Y.; Kaplancıklı, Z.A. Design and synthesis of new Benzothiazole compounds as selective hMAO-B inhibitors. Molecules, 2017, 22(12), 2187-2200.
[http://dx.doi.org/10.3390/molecules22122187] [PMID: 29232838]
[9]
Dezsi, L.; Vecsei, L. Monoamine oxidase B inhibitors in parkinson’s disease. CNS Neurol. Disord. Drug Targets, 2017, 16(4), 425-439.
[http://dx.doi.org/10.2174/1871527316666170124165222] [PMID: 28124620]
[10]
Mason, R.P.; Olmstead, E.G.; Jacob, R.F. Antioxidant activity of the monoamine oxidase B inhibitor lazabemide. Biochem. Pharmacol., 2000, 60(5), 709-716.
[http://dx.doi.org/10.1016/S0006-2952(00)00374-9] [PMID: 10927030]
[11]
Tatton, W.G.; Chalmers-Redman, R.M.; Ju, W.Y.; Wadia, J.; Tatton, N.A. Apoptosis in neurodegenerative disorders: potential for therapy by modifying gene transcription. J. Neural Transm. Suppl., 1997, 49, 245-268.
[http://dx.doi.org/10.1007/978-3-7091-6844-8_25] [PMID: 9266433]
[12]
Solayman, M.; Islam, M.A.; Alam, F.; Khalil, M.I.; Kamal, M.A.; Gan, S.H. Natural products combating neurodegenera-tion: Parkinson’s disease. Curr. Drug Metab., 2017, 18(1), 50-61.
[http://dx.doi.org/10.2174/1389200217666160709204826] [PMID: 27396919]
[13]
Fu, W.; Zhuang, W.; Zhou, S.; Wang, X. Plant-derived neuroprotective agents in Parkinson’s disease. Am. J. Transl. Res., 2015, 7(7), 1189-1202.
[PMID: 26328004]
[14]
Ding, Y.; Xin, C.; Zhang, C.W.; Lim, K.L.; Zhang, H.; Fu, Z.; Li, L.; Huang, W. Natural molecules from Chinese Herbs pro-tecting against Parkinson’s disease via anti-oxidative stress. Front. Aging Neurosci., 2018, 10, 246.
[http://dx.doi.org/10.3389/fnagi.2018.00246] [PMID: 30233351]
[15]
Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod., 2012, 75(3), 311-335.
[http://dx.doi.org/10.1021/np200906s] [PMID: 22316239]
[16]
Ji, H.F.; Li, X.J.; Zhang, H.Y. Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep., 2009, 10(3), 194-200.
[http://dx.doi.org/10.1038/embor.2009.12] [PMID: 19229284]
[17]
Harvey, A.L. Natural products in drug discovery. Drug Discov. Today, 2008, 13(19-20), 894-901.
[http://dx.doi.org/10.1016/j.drudis.2008.07.004] [PMID: 18691670]
[18]
Carter, G.T. Natural products and Pharma 2011: strategic changes spur new opportunities. Nat. Prod. Rep., 2011, 28(11), 1783-1789.
[http://dx.doi.org/10.1039/c1np00033k] [PMID: 21909580]
[19]
Gullo, V.P.; McAlpine, J.; Lam, K.S.; Baker, D.; Petersen, F. Drug discovery from natural products. J. Ind. Microbiol. Biotechnol., 2006, 33(7), 523-531.
[http://dx.doi.org/10.1007/s10295-006-0107-2] [PMID: 16544162]
[20]
Thomford, N.E.; Senthebane, D.A.; Rowe, A.; Munro, D.; Seele, P.; Maroyi, A.; Dzobo, K. Natural products for drug discovery in the 21st century: innovations for novel drug dis-covery. Int. J. Mol. Sci., 2018, 19(6), 1578.
[http://dx.doi.org/10.3390/ijms19061578] [PMID: 29799486]
[21]
Joshi, R.K. Chemical composition and antimicrobial activity of the essential oil of Ocimum basilicum L. (sweet basil) from Western Ghats of North West Karnataka, India. Anc. Sci. Life, 2014, 33(3), 151-156.
[http://dx.doi.org/10.4103/0257-7941.144618] [PMID: 25538349]
[22]
Lionta, E.; Spyrou, G.; Vassilatis, D.K.; Cournia, Z. Structure-based virtual screening for drug discovery: principles, applications and recent advances. Curr. Top. Med. Chem., 2014, 14(16), 1923-1938.
[http://dx.doi.org/10.2174/1568026614666140929124445] [PMID: 25262799]
[23]
Gomeni, R.; Bani, M.; D’Angeli, C.; Corsi, M.; Bye, A. Computer-assisted drug development (CADD): an emerging technology for designing first-time-in-man and proof-of-concept studies from preclinical experiments. Eur. J. Pharm. Sci., 2001, 13(3), 261-270.
[http://dx.doi.org/10.1016/S0928-0987(01)00111-7] [PMID: 11384848]
[24]
Veselovsky, A.V.; Ivanov, A.S. Strategy of computer-aided drug design. Curr. Drug Targets Infect. Disord., 2003, 3(1), 33-40.
[http://dx.doi.org/10.2174/1568005033342145] [PMID: 12570731]
[25]
Rester, U. From virtuality to reality - Virtual screening in lead discovery and lead optimization: a medicinal chemistry perspective. Curr. Opin. Drug Discov. Devel., 2008, 11(4), 559-568.
[PMID: 18600572]
[26]
Rollinger, J.M.; Stuppner, H.; Langer, T. Virtual screening for the discovery of bioactive natural products. Prog. Drug Res, 2008, 65(211), 213-249.
[http://dx.doi.org/10.1007/978-3-7643-8117-2_6] [PMID: 18084917]
[27]
Lavecchia, A.; Di Giovanni, C. Virtual screening strategies in drug discovery: a critical review. Curr. Med. Chem., 2013, 20(23), 2839-2860.
[http://dx.doi.org/10.2174/09298673113209990001] [PMID: 23651302]
[28]
Reddy, A.S.; Pati, S.P.; Kumar, P.P.; Pradeep, H.N.; Sastry, G.N. Virtual screening in drug discovery -- a computational perspective. Curr. Protein Pept. Sci., 2007, 8(4), 329-351.
[http://dx.doi.org/10.2174/138920307781369427] [PMID: 17696867]
[29]
Benod, C.; Carlsson, J.; Uthayaruban, R.; Hwang, P.; Irwin, J.J.; Doak, A.K.; Shoichet, B.K.; Sablin, E.P.; Fletterick, R.J. Structure-based discovery of antagonists of nuclear receptor LRH-1. J. Biol. Chem., 2013, 288(27), 19830-19844.
[http://dx.doi.org/10.1074/jbc.M112.411686] [PMID: 23667258]
[30]
Cheng, T.; Li, Q.; Zhou, Z.; Wang, Y.; Bryant, S.H. Structure-based virtual screening for drug discovery: a problem-centric review. AAPS J., 2012, 14(1), 133-141.
[http://dx.doi.org/10.1208/s12248-012-9322-0] [PMID: 22281989]
[31]
Andricopulo, A.D.; Salum, L.B.; Abraham, D.J. Structure-based drug design strategies in medicinal chemistry. Curr. Top. Med. Chem., 2009, 9(9), 771-790.
[http://dx.doi.org/10.2174/156802609789207127] [PMID: 19754394]
[32]
Yu, W.; MacKerell, A.D. Jr Computer-Aided drug design methods. Methods Mol. Biol., 2017, 1520, 85-106.
[http://dx.doi.org/10.1007/978-1-4939-6634-9_5] [PMID: 27873247]
[33]
McInnes, C. Virtual screening strategies in drug discovery. Curr. Opin. Chem. Biol., 2007, 11(5), 494-502.
[http://dx.doi.org/10.1016/j.cbpa.2007.08.033] [PMID: 17936059]
[34]
Willett, P. Similarity-based virtual screening using 2D fingerprints. Drug Discov. Today, 2006, 11(23-24), 1046-1053.
[http://dx.doi.org/10.1016/j.drudis.2006.10.005] [PMID: 17129822]
[35]
Ehrman, T.M.; Barlow, D.J.; Hylands, P.J. Virtual screening of Chinese herbs with Random Forest. J. Chem. Inf. Model., 2007, 47(2), 264-278.
[http://dx.doi.org/10.1021/ci600289v] [PMID: 17381165]
[36]
Schulz-Gasch, T.; Stahl, M. Scoring functions for protein-ligand interactions: a critical perspective. Drug Discov. Today. Technol., 2004, 1(3), 231-239.
[http://dx.doi.org/10.1016/j.ddtec.2004.08.004] [PMID: 24981490]
[37]
van Montfort, R.L.M.; Workman, P. Structure-based drug design: aiming for a perfect fit. Essays Biochem., 2017, 61(5), 431-437.
[http://dx.doi.org/10.1042/EBC20170052] [PMID: 29118091]
[38]
Ferreira, L.G.; Dos Santos, R.N.; Oliva, G.; Andricopulo, A.D. Molecular docking and structure-based drug design strategies. Molecules, 2015, 20(7), 13384-13421.
[http://dx.doi.org/10.3390/molecules200713384] [PMID: 26205061]
[39]
Azam, S.S.; Abbasi, S.W. Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines. Theor. Biol. Med. Model., 2013, 10, 63-79.
[http://dx.doi.org/10.1186/1742-4682-10-63] [PMID: 24156411]
[40]
de Ruyck, J.; Brysbaert, G.; Blossey, R.; Lensink, M.F. Molecular docking as a popular tool in drug design, an in silico travel. Adv. Appl. Bioinform. Chem., 2016, 9, 1-11.
[http://dx.doi.org/10.2147/AABC.S105289] [PMID: 27390530]
[41]
Kroemer, R.T. Structure-based drug design: docking and scoring. Curr. Protein Pept. Sci., 2007, 8(4), 312-328.
[http://dx.doi.org/10.2174/138920307781369382] [PMID: 17696866]
[42]
Śledź, P.; Caflisch, A. Protein structure-based drug design: from docking to molecular dynamics. Curr. Opin. Struct. Biol., 2018, 48, 93-102.
[http://dx.doi.org/10.1016/j.sbi.2017.10.010] [PMID: 29149726]
[43]
Naeem, S.; Hylands, P.; Barlow, D. Docking studies of chlorogenic acid against aldose redutcase by using Molgro Virtual Docker software. J. Appl. Pharm. Sci., 2013, 3(01), 13-20.
[44]
Anwar, M.F.; Khalid, R.; Hasanain, A.; Naeem, S.; Zarina, S.; Abidi, S.H.; Ali, S. Integrated cheminformatics- molecular docking approach to drug discovery against viruses. Infect. Disord. Drug Targets, 2019, 19, 1-10.
[PMID: 30345931]
[45]
Siddiqui, S.; Anwar, M.F.; Naeem, S.; Abidi, S.H.; Zarina, S.; Ali, S. Simian Virus 40 Large T Antigen as a model to test the efficacy of flouroquinolones against viral helicases. Bioinformation, 2018, 14(2), 75-79.
[http://dx.doi.org/10.6026/97320630014075] [PMID: 29618903]
[46]
Naeem, S.; Asif, U.; Sherwani, A.K. Bano, K.; Shoaib, M.H.; Akhtar, N. Docking studies of Febuxostat by using MolDock software. Int. J. Biol. Biotechnol., 2012, 9(4), 367-371.
[47]
Meng, X.Y.; Zhang, H.X.; Mezei, M.; Cui, M. Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des, 2011, 7(2), 146-157.
[http://dx.doi.org/10.2174/157340911795677602] [PMID: 21534921]
[48]
Lounnas, V.; Ritschel, T.; Kelder, J.; McGuire, R.; Bywater, R.P.; Foloppe, N. Current progress in Structure-Based Rational Drug Design marks a new mindset in drug discovery. Comput. Struct. Biotechnol J., 2013. 5e201302011
[http://dx.doi.org/10.5936/csbj.201302011] [PMID: 24688704]
[49]
Wang, X.; Song, K.; Li, L.; Chen, L. Structure-based drug design strategies and challenges. Curr. Top. Med. Chem., 2018, 18(12), 998-1006.
[http://dx.doi.org/10.2174/1568026618666180813152921] [PMID: 30101712]
[50]
Kim, S.; Thiessen, P.A.; Bolton, E.E.; Chen, J.; Fu, G.; Gin-dulyte, A.; Han, L.; He, J.; He, S.; Shoemaker, B.A.; Wang, J.; Yu, B.; Zhang, J.; Bryant, S.H. PubChem substance and compound databases. Nucleic Acids Res., 2016, 44, D1202-D1213.
[http://dx.doi.org/10.1093/nar/gkv951] [PMID: 26400175]
[51]
O’Boyle, N.M.; Banck, M.; James, C.A.; Morley, C.; Vandermeersch, T.; Hutchison, G.R. Open Babel: an open chemical toolbox. J. Cheminform., 2011, 3, 33-48.
[http://dx.doi.org/10.1186/1758-2946-3-33] [PMID: 21982300]
[52]
Mauri, A.; Consonni, V.; Pavan, M.; Todeschini, R. Dragon software: an easy approach to molecular decriptor calcula-tions. MATCH Commun. Math. Comput. Chem., 2006, 56, 237-248.
[53]
Berman, H.M.; Westbrook, J.; Feng, Z.; Gilliland, G.; Bhat, T.N.; Weissig, H.; Shindyalov, I.N.; Bourne, P.E. The protein data bank. Nucleic Acids Res., 2000, 28(1), 235-242.
[http://dx.doi.org/10.1093/nar/28.1.235] [PMID: 10592235]
[54]
Binda, C.; Aldeco, M.; Geldenhuys, W.J.; Tortorici, M.; Mattevi, A.; Edmondson, D.E. Molecular insights into human Monoamine Oxidase B inhibition by the Glitazone antidiabe-tes drugs. Med. Chem. Lett., 2012, 3, 39-42.
[http://dx.doi.org/10.1021/ml200196p]
[55]
Storn, R.; Price, K. Differential evolution-A simple and effi-cient adaptive scheme for global optimization over continuous spaces. J. Glob. Optim., 1997, 11, 341.
[http://dx.doi.org/10.1023/A:1008202821328]
[56]
Thomsen, R.; Christensen, M.H. MolDock: a new technique for high-accuracy molecular docking. J. Med. Chem., 2006, 49(11), 3315-3321.
[http://dx.doi.org/10.1021/jm051197e] [PMID: 16722650]
[57]
Paul, S.B.; Choudhury, S. Computational analysis of the activity of pongachalcone I against highly resistant bacteria Pseudomonas putida. Bioinformation, 2010, 4(10), 473-477.
[http://dx.doi.org/10.6026/97320630004473] [PMID: 20975912]
[58]
Gehlhaar, D.K.; Verkhivker, G.M.; Rejto, P.A.; Sherman, C.J.; Fogel, D.B.; Fogel, L.J.; Freer, S.T. Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming. Chem. Biol., 1995, 2(5), 317-324.
[http://dx.doi.org/10.1016/1074-5521(95)90050-0] [PMID: 9383433]
[59]
Yang, J.M.; Chen, C.C. GEMDOCK: a generic evolutionary method for molecular docking. Proteins, 2004, 55(2), 288-304.
[http://dx.doi.org/10.1002/prot.20035] [PMID: 15048822]
[60]
Binda, C.; Li, M.; Hubalek, F.; Restelli, N.; Edmondson, D.E.; Mattevi, A. Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc. Natl. Acad. Sci. USA, 2003, 100(17), 9750-9755.
[http://dx.doi.org/10.1073/pnas.1633804100] [PMID: 12913124]
[61]
Wimo, A.; Jonsson, L.; Winblad, B. An estimate of the worldwide prevalence and direct costs of dementia in 2003. Dement. Geriatr. Cogn. Disord., 2006, 21(3), 175-181.
[http://dx.doi.org/10.1159/000090733] [PMID: 16401889]
[62]
Sandler, M.; Glover, V.; Clow, A.; Jarman, J. Monoamine oxidase-B, monoamine oxidase-B inhibitors, and Parkinson’s disease. A role for superoxide dismutase? Adv. Neurol., 1993, 60, 238-241.
[PMID: 8420141]
[63]
Khair-ul-Bariyah, S.; Ahmed, D.; Ikram, M. Ocimum basilicum: a review on phytochemical and pharmacological studies. Pak. J. Chem., 2012, 2(2), 78-85.
[http://dx.doi.org/10.15228/2012.v02.i02.p05]
[64]
Ahmad, M.; Naz, S.B.; Sharif, A.; Akram, M.; Saeed, M.A. Biological and pharmacological properties of the sweet basil (Ocimum basilicum). Br. J. Pharm. Res., 2015, 7(5), 330-339.
[http://dx.doi.org/10.9734/BJPR/2015/16505]
[65]
Rubab, S.; Hussain, I.; Khan, B.A.; Unar, A.A.; Abbas, K.A.; Khichi, Z.H.; Khan, M.; Khanum, S.; Rehman, K.U.; Khan, H. Biomedical description of Ocimum basilicum L JIIMC, 2017, 1, 59-167.
[66]
Chaurasiya, N.D.; Ibrahim, M.A.; Muhammad, I.; Walker, L.A.; Tekwani, B.L. Monoamine oxidase inhibitory constituents of propolis: kinetics and mechanism of inhibition of recombinant human MAO-A and MAO-B. Molecules, 2014, 19(11), 18936-18952.
[http://dx.doi.org/10.3390/molecules191118936] [PMID: 25412041]
[67]
Andrade, J.M.; Dos Santos Passos, C.; Kieling Rubio, M.A.; Mendonça, J.N.; Lopes, N.P.; Henriques, A.T. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem. Biol. Interact., 2016, 254, 135-145.
[http://dx.doi.org/10.1016/j.cbi.2016.06.005] [PMID: 27270453]
[68]
Lee, M.H.; Lin, R.D.; Shen, L.Y.; Yang, L.L.; Yen, K.Y.; Hou, W.C. Monoamine oxidase B and free radical scavenging activities of natural flavonoids in Melastoma candidum D. Don. J. Agric. Food Chem., 2001, 49(11), 5551-5555.
[http://dx.doi.org/10.1021/jf010622j] [PMID: 11714358]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version465msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[08:52:20] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[08:52:20] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[08:52:20] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (123ms)time
  • Application (343ms)time
  • 1 x Application (73.66%)
    343ms
    1 x Booting (26.34%)
    123ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    37 statements were executed, 4 of which were duplicates, 33 unique. Show only duplicated260ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('51727266','',1,1740473540,1740473540) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740473540
      950μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('51727266','/article/98348',1,1740473540,1740473540)
      180μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 51727266 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 51727266) limit 1
      12.25msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 51727266
      • 1: 51727266
      • 2: 51727266
      • 3: 51727266
      • 4: 51727266
      • 5: 51727266
      • 6: 51727266
      • 7: 51727266
      • 8: 51727266
      • 9: 51727266
      • 10: 51727266
      • 11: 51727266
      • 12: 51727266
      • 13: 51727266
      • 14: 51727266
      • 15: 51727266
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=98348
      790μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 5 limit 1
      830μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 5
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=5) and sj.journal_id!=5 group by `j`.`nid`) as `aggregate_table`
      690μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=5) and sj.journal_id!=5 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      610μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=5) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.81msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=5) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.8msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '98348'
      1.34msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 98348
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '98348'
      2.33msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 98348
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '98348' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.02msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 98348
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      260μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      510μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 5 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      39.36msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 5 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      9.24msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 5 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      6.4msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 98348 limit 1
      1.42msalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 98348
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 98348 and content_type = 'article' order by status desc limit 1
      400μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 281 and cd.sub_disease_id = 297 and content_id!=98348 and cd.content_type = 'article' order by rand() limit 20
      159msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 171964 limit 1
      270μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 171964
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      250μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CCADD' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      300μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CCADD
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '98348' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      380μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '10064' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      350μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2727' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      310μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2727) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2727) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2727)
      8.22msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 10064) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 10064) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 10064)
      600μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 98348) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 98348) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51727266 and j.to_ip >=51727266 )) and ((j.from_date <= 1740473540 and j.to_date >= 1740473540 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 98348)
      640μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '420' and is_uploaded = 1 and issue_id = 10064 order by cast(first_page as SIGNED) desc limit 1
      530μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 420
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '434' and is_uploaded = 1 and issue_id = 10064 order by cast(first_page as SIGNED) asc limit 1
      490μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 434
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      200μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      200μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 98348 limit 1
      2.31msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 98348
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 5 and `b`.`banner_from_date` <= 1740473540 and `b`.`banner_to_date` >= 1740473540 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.14msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 5
      • 3: 1740473540
      • 4: 1740473540
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 5 and `b`.`banner_from_date` <= 1740473540 and `b`.`banner_to_date` >= 1740473540 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 5
      • 3: 1740473540
      • 4: 1740473540
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='197adca3c4b361d00758e13283ffc4e3'
      220μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        qIXQ2qPE8nL31YUHf9dJRwJiKpBVqO0EJ3Y1axyt
        uc_cart_id
        197adca3c4b361d00758e13283ffc4e3
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/98348" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/98348
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6Im1NNGkzaFNxQlFCaUtCMU1pMElrVHc9PSIsInZhbHVlIjoidEh2OUhucTJUeE9IS21XMGM3SVdsMzdaK1NHUDViRFJNU1kwb2ZHS09mbz0iLCJtYWMiOiI5YWY2NmVlODllNTcwMTA5NGYxMGQ2NDNhMDM3YWQwMmJjMzRhNmM1MzhlNGEyNDJjNGE0NmQzNGM2NmU3OWZlIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6Im1NNGkzaFNxQlFCaUtCMU1pMElrVHc9PSIsInZhbHVlIjoidEh2OUhucTJUeE9IS21XMGM3SVdsMzdaK1NHUDViRFJNU1kwb2ZHS09mbz0iLCJtYWMiOiI5YWY2NmVlODllNTcw" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 08:52:20 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InVRbzBBOFVUMTBCZGEwaHZhUGs0TUE9PSIsInZhbHVlIjoieWQ4NW0zYjlNMG10M2ZUZ3dYUmZ5bTRlOWIyUGR5MHNyRkpVVmRxaDVsaTVXSmFCdzlxdnV3Qy9BZE1jNnFldzg3VktkZ2NTV1hRdVdEc1Q1ZE4xVkFqK0hMNkdrV09YTkw0ZU9qTGVZMlRjTnhQRHdCaEtsSlFNNXNNVHF3eGUiLCJtYWMiOiI0ZDY3Zjk1Nzg5NjhiYWYwODNjYmU2Njc5N2I0NGRmYWNhMDIxMjIwZTNiMzRlYzVmNDFjMzk0MzdmNTBiMDc1IiwidGFnIjoiIn0%3D; expires=Thu, 27 Feb 2025 20:52:20 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InVRbzBBOFVUMTBCZGEwaHZhUGs0TUE9PSIsInZhbHVlIjoieWQ4NW0zYjlNMG10M2ZUZ3dYUmZ5bTRlOWIyUGR5MHNyRkpVVmRxaDVsaTVXSmFCdzlxdnV3Qy9BZE1jNnFldzg3VktkZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlFlMm52dkUxN25zWWVqVnI5aFZyK1E9PSIsInZhbHVlIjoiQVlxWDE5NlgweEk3K2Q4TGQxQmMwZWl2LzZQeTNWWFZJa012ZkM0d2dMUWNWVW1GN0xHSktwcFBSdjl6TUtaMFVXZWFMb0ducEo5YW83THkzbUt5LzJ1SXRVckFyZElPcEpCNm1RZk9LRG13TWhPZWFCS0o0VVNHei9YdDdtUHAiLCJtYWMiOiIyNmE5MDI1NjJiOGNkNzQ5OTg5MTI3NWYwMjJjMzQ3ODFmYjQ4MDU3NGM5ZGEyYmYyYjI2OGRmNzBkZjUwZTJhIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IlFlMm52dkUxN25zWWVqVnI5aFZyK1E9PSIsInZhbHVlIjoiQVlxWDE5NlgweEk3K2Q4TGQxQmMwZWl2LzZQeTNWWFZJa012ZkM0d2dMUWNWVW1GN0xHSktwcFB" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InVRbzBBOFVUMTBCZGEwaHZhUGs0TUE9PSIsInZhbHVlIjoieWQ4NW0zYjlNMG10M2ZUZ3dYUmZ5bTRlOWIyUGR5MHNyRkpVVmRxaDVsaTVXSmFCdzlxdnV3Qy9BZE1jNnFldzg3VktkZ2NTV1hRdVdEc1Q1ZE4xVkFqK0hMNkdrV09YTkw0ZU9qTGVZMlRjTnhQRHdCaEtsSlFNNXNNVHF3eGUiLCJtYWMiOiI0ZDY3Zjk1Nzg5NjhiYWYwODNjYmU2Njc5N2I0NGRmYWNhMDIxMjIwZTNiMzRlYzVmNDFjMzk0MzdmNTBiMDc1IiwidGFnIjoiIn0%3D; expires=Thu, 27-Feb-2025 20:52:20 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InVRbzBBOFVUMTBCZGEwaHZhUGs0TUE9PSIsInZhbHVlIjoieWQ4NW0zYjlNMG10M2ZUZ3dYUmZ5bTRlOWIyUGR5MHNyRkpVVmRxaDVsaTVXSmFCdzlxdnV3Qy9BZE1jNnFldzg3VktkZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6IlFlMm52dkUxN25zWWVqVnI5aFZyK1E9PSIsInZhbHVlIjoiQVlxWDE5NlgweEk3K2Q4TGQxQmMwZWl2LzZQeTNWWFZJa012ZkM0d2dMUWNWVW1GN0xHSktwcFBSdjl6TUtaMFVXZWFMb0ducEo5YW83THkzbUt5LzJ1SXRVckFyZElPcEpCNm1RZk9LRG13TWhPZWFCS0o0VVNHei9YdDdtUHAiLCJtYWMiOiIyNmE5MDI1NjJiOGNkNzQ5OTg5MTI3NWYwMjJjMzQ3ODFmYjQ4MDU3NGM5ZGEyYmYyYjI2OGRmNzBkZjUwZTJhIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IlFlMm52dkUxN25zWWVqVnI5aFZyK1E9PSIsInZhbHVlIjoiQVlxWDE5NlgweEk3K2Q4TGQxQmMwZWl2LzZQeTNWWFZJa012ZkM0d2dMUWNWVW1GN0xHSktwcFB" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "qIXQ2qPE8nL31YUHf9dJRwJiKpBVqO0EJ3Y1axyt" "uc_cart_id" => "197adca3c4b361d00758e13283ffc4e3" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/98348" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 08:52:20GET/article/98348314371