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Review Article

基础切除修复途径中的氧化还原调节：新老参与者成为癌症治疗的目标

卷 27, 期 12, 2020

页: [1901 - 1921] 页: 21

弟呕挨: 10.2174/0929867326666190430092732

价格: $65

摘要

背景：活性氧（ROS）是正常细胞代谢过程（例如线粒体氧化磷酸化）的副产物。虽然低水平的ROS是重要的信号分子，但高水平的ROS可能会破坏蛋白质，脂质和DNA。确实，氧化性DNA损伤是哺乳动物基因组中最常见的损伤类型，与人类疾病（例如癌症和神经退行性疾病）有关。尽管氧化性DNA损伤主要通过碱基切除修复（BER）途径清除，但最近的证据表明，其他途径，例如核苷酸切除修复（NER）和错配修复（MMR）也可以参与这些病变的清除。氧化性DNA损伤的最常见形式之一是碱基损伤8-氧鸟嘌呤（8-oxoG），如果不进行修复，可能会导致复制过程中G：C向A：T的转化，这是一种常见的诱变特征，可导致细胞凋亡。转型。 目的：修复氧化性DNA损伤，包括8-oxoG碱基损伤，涉及一系列酶促反应中许多蛋白质之间的功能相互作用。这篇综述描述了8-oxoG损害的BER初始阶段所涉及的关键蛋白的作用和氧化还原调节，即Apurinic / Apyrimidinic核酸内切酶1（APE1），人8-氧代鸟嘌呤DNA糖基化酶1（hOGG1）和链DNA结合蛋白1（hSSB1）。此外，讨论了靶向这些关键蛋白在癌症中的治疗潜力和方式。 结论：越来越明显的是某些DNA修复蛋白在多种修复途径中起作用。抑制这些因素将为开发更有效的癌症疗法提供有吸引力的策略。

关键词: ROS，BER，APE1，hOGG1，hSSB1 / NABP2 / OBFC2B，DNA修复，癌症治疗剂。

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