摘要
背景:急性髓细胞性白血病(AML)是一种遗传异质性疾病,其特征是骨髓中的前体髓系谱系细胞不受控制地增殖。 AML的特征还在于患者由于复发而长期生存结果较差。为了了解AML的生物学异质性,已经进行了许多努力,因此开发新疗法的挑战是巨大的。 G蛋白偶联受体(GPCRs)是跨膜蛋白的大型药物靶向家族,并且异常的GPCR表达和GPCR介导的信号传导与AML的白血病发生有关。这篇综述旨在鉴定GPCR信号传导的分子参与者,重点是造血系统,该系统参与AML以帮助开发新的药物靶标和治疗策略。 方法:我们对书目数据库进行了详尽而结构化的搜索,以研究GPCR,GPCR信号和AML中的表达为重点。 结果与结论:许多科学报告被发现具有令人信服的证据,证明异常的GPCR表达和扰动的GPCR介导的信号传导参与了AML的发展。对AML中GPCR的综合分析为预后,疾病监测和治疗指导提供了潜在的临床生物标志物。它还将有助于提供标记面板以进行AML监视。我们得出的结论是,GPCR介导的信号传导有助于AML的白血病发生,并假定基于质谱的主要AML细胞的蛋白质谱分析将加快AML潜在GPCR相关生物标记物的发现。
关键词: 白血病,AML,G蛋白,GPCR,细胞信号,临床生物标志物。
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