Login Register Cart 0
Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Anti-Inflammatory, Antiulcer and Anticancer Activities of Saponin Isolated from the Fruits of Ziziphus jujuba

Author(s): Ajay M. Chowdari and D. Giles*

Volume 10, Issue 4, 2020

Page: [395 - 399] Pages: 5

DOI: 10.2174/2210315509666190429145610

Price: $65

Abstract

Background: Ziziphus jujuba mill was commonly used for its anti-inflammatory activity in traditional system of medicine.

Objective: The purpose of this study was to examine the isolates of methanolic extract from the fruits of Ziziphus jujuba Mill for its antiulcer, anti-inflammatory, and anticancer activity.

Methods: Methanolic extracts of Ziziphus jujuba Mill were subjected to chromatography and eluted using ethyl acetate: methanol mixture and investigated for its structural features using IR, 1H NMR, 13C NMR and mass spectral data. The isolated compound was evaluated for its in vitro COX-2 inhibition studies, cytotoxicity studies, in vivo anti-inflammatory, antiulcer and anticancer activity.

Results: The spectral data revealed that the backbone of the isolate was 3-O-α-L-rhamnopyranosyl- (1→6)-β-D-glucopyranosyl jujubogenin-20-O-(2,3,4-O-triacetyl)-α-L-rhamnopyranoside. The isolated compound showed a significant reduction in inflammation and edema. Moderate anticancer activity was also observed for the isolate.

Conclusion: It was concluded that the isolated saponin possesses moderate antiulcer, antiinflammatory, and anticancer activity which could help in the identification of leads for the treatment of cancer-related inflammation.

Keywords: Anticancer, anti-inflammatory, antiulcer, saponin, Ziziphus jujube, methanolic isolate.

Graphical Abstract

[1]
Seth, S.D.; Sharma, B. Medicinal plants in India. Indian J. Med. Res., 2004, 120(1), 9-11.
[PMID: 15299226]
[2]
Mahajan, R.T.; Chopda, M.Z. Phyto-pharmacology of Ziziphus jujuba Mill - A plant review. Pharmacogn. Rev., 2009, 6, 320-329.
[3]
Guo, S.; Duan, J.A.; Tang, Y.; Su, S.; Shang, E.; Ni, S.; Qian, D. High-performance liquid chromatography--Two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis. J. Pharm. Biomed. Anal., 2009, 49(5), 1296-1302.
[http://dx.doi.org/10.1016/j.jpba.2009.03.006] [PMID: 19359121]
[4]
Prasanna, K.S.R.; Syed, M.B.A.; Prem, K.N.; Asad, M.; Deepak, K.K. Protective effect of Ziziphus Jujuba fruit extract against Paracetamol and Thioacetamide induced hepatic damage in rats. Int. J. Pharmacol., 2009, 7(1), 1-8.
[5]
Kumar, S.; Ganachari, M.S.; Nagoor, V.S. Anti-inflammatory activity of Ziziphus jujuba Lam. leaves extract in rats. J. Nat. Rem., 2004, 4, 183-185.
[6]
Huang, X.; Kojima-Yuasa, A.; Norikura, T.; Kennedy, D.O.; Hasuma, T.; Matsui-Yuasa, I. Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells. Am. J. Chin. Med., 2007, 35(3), 517-532.
[http://dx.doi.org/10.1142/S0192415X0700503X] [PMID: 17597510]
[7]
Chopda, M.Z.; Mahajan, R.T. Wound healing plants of Jalgaon district of Maharashtra state, India. Ethnobot Leaflets., 2009, 13, 1-32.
[8]
Lee, S.M.; Park, J.G.; Lee, Y.H.; Lee, C.G.; Min, B.S.; Kim, J.H.; Lee, H.K. Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba. Biol. Pharm. Bull., 2004, 27(11), 1883-1886.
[http://dx.doi.org/10.1248/bpb.27.1883] [PMID: 15516743]
[9]
Peng, W.H.; Hsieh, M.T.; Lee, Y.S.; Lin, Y.C.; Liao, J. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. J. Ethnopharmacol., 2000, 72(3), 435-441.
[http://dx.doi.org/10.1016/S0378-8741(00)00255-5] [PMID: 10996283]
[10]
Ganachari, M.S.; Kumar, S. Effect of Ziziphus jujuba leaf extracts on body weight, food intake and serum lipid levels in sucrose-induced obsess rats. Indian J. Pharm. Sci., 2004, 66, 363-365.
[11]
Ganachari, M.S.; Kumar, S. Antiulcer properties of Ziziphus jujuba Lam. leaves extract in rats. J. Nat. Rem., 2004, 4(2), 103-108.
[12]
Zhang, H.; Jiang, L.; Ye, S.; Ye, Y.; Ren, F. Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China. Food Chem. Toxicol., 2010, 48(6), 1461-1465.
[http://dx.doi.org/10.1016/j.fct.2010.03.011] [PMID: 20230870]
[13]
Jiang, J.G.; Huang, X.J.; Chen, J. Separation and purification of saponins from semen Ziziphus jujuba and their sedative and hypnotic effects. J. Pharm. Pharmacol., 2007, 59(8), 1175-1180.
[http://dx.doi.org/10.1211/jpp.59.8.0017] [PMID: 17725862]
[14]
Herbert, L.M.; Bruce, P.H.; George, P.D. Reduction of sweetness judgments by extracts from the leaves of Ziziphus jujuba. Physiol. Behav., 1979, 17, 313-317.
[15]
Shirdel, Z.; Madani, H.; Mirbadalzadeh, R. Investigation into the hypoglycemic effect of hydroalcoholic extract of Ziziphus jujuba Leaves on blood glucose and lipids in Alloxan-Induced diabetes in rats. IJDLD, 2009, 8, 13-19.
[16]
Gupta, M.; Mazumder, U.K.; Vamsi, M.L.; Sivakumar, T.; Kandar, C.C. Anti-steroidogenic activity of the two Indian medicinal plants in mice. J. Ethnopharmacol., 2004, 90(1), 21-25.
[http://dx.doi.org/10.1016/j.jep.2003.09.002] [PMID: 14698503]
[17]
Yogendr, B.; Kalpana, P.; Mohan, S.M.R.; Sunil, J.; Sampada, U. Antiulcer activity of Melia azedarach Linn. in aspirin induced and pylorus ligated rats. J. Pharm. Res., 2009, 2, 1456-1459.
[18]
Nezić, L.; Skrbić, R.; Dobrić, S.; Stojiljković, M.P.; Jaćević, V.; Satara, S.S.; Milovanović, Z.A.; Stojaković, N. Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation. Basic Clin. Pharmacol. Toxicol., 2009, 104(3), 185-191.
[http://dx.doi.org/10.1111/j.1742-7843.2008.00302.x] [PMID: 19210496]
[19]
Solanki, H.K.; Shah, D.A.; Maheriya, P.M.; Patel, C.A. Evaluation of anti-inflammatory activity of probiotic on carrageenan-induced paw edema in wistar rats. Int. J. Biol. Macromol., 2015, 72, 1277-1282.
[http://dx.doi.org/10.1016/j.ijbiomac.2014.09.059]
[20]
Zahran, M.A.H.; Salem, T.A.R.; Samaka, R.M.; Agwa, H.S.; Awad, A.R. Design, synthesis and antitumor evaluation of novel thalidomide dithiocarbamate and dithioate analogs against ehrlich ascites carcinoma-induced solid tumor in Swiss albino mice. Bioorg. Med. Chem., 2008, 16, 9708-9718.
[http://dx.doi.org/10.1016/j.bmc.2008.09.071]
[21]
Thomas, V.; Giles, D.; Basavarajaswamy, G.P.M.; Das, A.K.; Patel, A. Coumarin derivatives as anti-inflammatory and anticancer agents. Anticancer. Agents Med. Chem., 2017, 17(3), 415-423.
[http://dx.doi.org/10.2174/1871520616666160902094739] [PMID: 27592545]
[22]
Maciuk, A.; Lavaud, C.; Thépenier, P.; Jacquier, M.J.; Ghédira, K.; Zèches-Hanrot, M. Four new dammarane saponins from Zizyphus lotus. J. Nat. Prod., 2004, 67(10), 1639-1643.
[http://dx.doi.org/10.1021/np0499362] [PMID: 15497932]

Rights & Permissions Print Cite
Article Metrics
15
2
© 2024 Bentham Science Publishers | Privacy Policy