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Pharmaceutical Nanotechnology

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ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

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Review Article

Bioinspired Smart Nanosystems in Advanced Therapeutic Applications

Author(s): Satya Prakash Singh*, Anup Kumar Sirbaiya and Anuradha Mishra

Volume 7, Issue 3, 2019

Page: [246 - 256] Pages: 11

DOI: 10.2174/2211738507666190425122822

Abstract

Background: Nanoparticle technologies used for human administration must be designed to interact with a living host environment. The idea about bioinspired smart drug delivery carriers includes the development of biocompatible nanomaterials which can be further loaded with the drug for specific targeted drug delivery applications.

Objective: Biosmart nanosystems are used for several applications in the delivery of drugs and pharmaceuticals for their therapeutic applications like biological markers, diagnostic purposes such as imaging applications and also for gene therapy. Thus, the bioinspired nanocarriers are capable of carrying biologically active molecules to the target sites. This bioinspired nanosystem constitutes of lipids, polymers and biomaterials which utilizes various responsive sensors for targeted drug delivery systems. However, external conditions such as heat, light, magnetic or electric field and ultrasounds, along with temperature, altered pH and ionic strength can affect the bioinspired smart nanosystem for drug delivery.

Conclusion: The present review focuses on challenges for the development of bioinspired smart nanocarriers for the management of various disorders.

Keywords: Biosmart drug delivery systems, endogenous stimuli, exogenous stimuli, multiresponsive, thermoresponsive, Nanosystems.

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[1]
Mancin F, Scrimin P, Tecilla P, Tonellato U. Amphiphilic metalloaggregates: catalysis, transport, and sensing. Coord Chem Rev 2009; 253: 2150-65.
[2]
Kostarelos K. Rational design and engineering of delivery systems for therapeutics: biomedical exercises in colloid and surface science. Adv Colloid Interface Sci 2003; 106: 147-68.
[3]
Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP, Wiesner MR. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 2009; 4: 634.
[4]
Usmani A, Mishra A, Ahmad M. Nanomedicines: a theranostic approach for hepatocellular carcinoma. Artif Cells Nanomed Biotechnol 2018; 46: 680-90.
[5]
Hruby M, Filippov SK, Štepánek P. Smart polymers in drug delivery systems on crossroads: Which way deserves following? Eur Polym J 2015; 65: 82-97.
[6]
Roy D, Cambre JN, Sumerlin BS. Future perspectives and recent advances in stimuli-responsive materials. Prog Polym Sci 2010; 35: 278-301.
[7]
Cheng R, Feng F, Meng F, Deng C, Feijen J, Zhong Z. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J Control Release 2011; 152: 2-12.
[8]
Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat Mater 2013; 12: 991-1003.
[9]
John JV, Johnson RP, Heo MS, Moon BK, Byeon SJ, Kim I. Polymer-block-polypeptides and polymerconjugated hybrid materials as stimuli-responsive nanocarriers for biomedical applications. J Biomed Nanotechnol 2015; 11: 1-39.
[10]
Salzano G, Costa DF, Torchilin VP. siRNA delivery by stimuli-sensitive nanocarriers. Curr Pharm Des 2015; 21: 4566-73.
[11]
Liu F, Li X, Zhang LY. Stimuli-responsive nanocarriers for drug delivery to the central nervous system. Curr Nanosci 2016; 12: 4-17.
[12]
Felber AE, Dufresne MH, Leroux JC. pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv Drug Deliv Rev 2012; 64: 979-92.
[13]
Kanamala M, Wilson WR, Yang M, Palmer BD, Wu Z. Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: a review. Biomaterials 2016; 85: 152-67.
[14]
Tu F, Lee D. Shape-changing and amphiphilicityreversing janus particles with pH-responsive surfactant properties. J Am Chem Soc 2014; 136: 9999-10006.
[15]
Álvarez-Bautista A, Duarte CMM, Mendizábal E, Katime I. Controlled delivery of drugs through smart pH-sensitive nanohydrogels for anti-cancer therapies: synthesis, drug release and cellular studies. Des Monomers Polym 2016; 19: 319-29.
[16]
Pourjavadi A, Tehrani ZM, Moghanaki AA. Folateconjugated pH-responsive nanocarrier designed for active tumor targeting and controlled release of gemcitabine. Pharm Res 2016; 33: 417-32.
[17]
Liu X, Yaszemski MJ, Lu L. Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin. Biomater Sci 2016; 4: 245-9.
[18]
Cao J, Guenther RH, Sit TL, Opperman CH, Lommel SA, Willoughby JA. Loading and release mechanism of red clover necrotic mosaic virus derived plant viral nanoparticles for drug delivery of doxorubicin. Small 2014; 10: 5126-36.
[19]
Hu J, Zhang G, Liu S. Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels. Chem Soc Rev 2012; 41: 5933-49.
[20]
Jhaveri A, Deshpande P, Torchilin V. Stimulisensitive nanopreparations for combination cancer therapy. J Control Release 2014; 190: 352-70.
[21]
Karimi M, Ghasemi A, Zangabad PS, et al. Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem Soc Rev 2016; 45: 1457-501.
[22]
Lu Y, Sun W, Gu Z. Stimuli-responsive nanomaterials for therapeutic protein delivery. J Control Release 2014; 194: 1-19.
[23]
Alvarez-Lorenzo C, Concheiro A. Smart drug delivery systems: from fundamentals to the clinic. Chem Commun 2014; 50: 7743-65.
[24]
Schroeder A, Honen R, Turjeman K, Gabizon A, Kost J, Barenholz Y. Ultrasound triggered release of cisplatin from liposomes in murine tumors. J Control Release 2009; 137: 63-8.
[25]
Sirsi SR, Borden MA. State-of-the-art materials for ultrasound-triggered drug delivery. Adv Drug Deliv Rev 2014; 72: 3-14.
[26]
Guiot C, Zullino S, Priano L, Cavalli R. The physics of drug-delivery across the blood-brain barrier. Ther Deliv 2016; 7: 153-6.
[27]
Chen SY, Hu SH, Liu TY. Magnetic-responsive nanoparticles for drug delivery. In: Alvarez-Lorenzo C, Concheiro A, Eds. Smart materials for drug delivery. Cambridge: The Royal Society of Chemistry 2013, 2, 32pp-4.
[28]
Yang C, Rait A, Pirollo KF, Dagata JA, Farkas N, Chang EH. Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo. Nanomedicine 2008; 4: 318-29.
[29]
Ge J, Neofytou E, Cahill TJ 3rd, Beygui RE, Zare RN. Drug release from electric-field-responsive nanoparticles. ACS Nano 2012; 6: 227-33.
[30]
Yi Q, Sukhorukov GB. UV light stimulated encapsulation and release by polyelectrolyte microcapsules. Adv Colloid Interface Sci 2014; 207: 280-9.
[31]
Yan Q, Hana D, Zhao Y. Main-chain photoresponsive polymers with controlled location of light-cleavable units: from synthetic strategies to structural engineering. Polym Chem 2013; 4: 5026-37.
[32]
Saxer T, Zumbuehl A, Müller B. The use of shear stress for targeted drug delivery. Cardiovasc Res 2013; 99: 328-33.
[33]
Oliveira E, Genovese D, Juris R, et al. Bioinspired systems for metal-ion sensing: new emissive peptide probes based on benzo[d]oxazole derivatives and their gold and silica nanoparticles. Inorg Chem 2011; 50: 8834-49.
[34]
McGrath ME, Sprengeler PA, Hill CM, et al. Peptide ketobenzoxazole inhibitors bound to cathepsin K. Biochemistry 2003; 42: 15018-28.
[35]
El-Boubbou K, Zhu DC, Vasileiou C, et al. Magnetic glyconanoparticles: a tool to detect, differentiate, and unlock the glyco-codes of cancer via magnetic resonance imaging. J Am Chem Soc 2010; 132: 4490-9.
[36]
Meyer MHF, Stehr M, Bhuju S, et al. Magnetic biosensor for the detection of Yersinia pesos. J Microbiol Methods 2007; 68: 218-24.
[37]
Runge VM, Kirsch JE, Thomas GS. High-dose applications of gadolinium chelates in magnetic resonance- imaging. Magn Reson Med 1991; 22: 358-63.
[38]
Chang SQ, Dai YD, Kang B, Han W, Mao L, Chen D. UV enhanced cytotoxicity of thiol-capped CdTe quantum dots in human pancreatic carcinoma cells. Toxicol Lett 2009; 188: 104-11.
[39]
Gu H, Xu K, Xu C, Xu B. Biofunctional magnetic nanoparticles for protein separation and pathogen detection. Chem Commun 2006; 9: 941-9.
[40]
Chen J, Zhang L, Paoli GC, et al. A real-time PCR method for the detection of Salmonella enterica from food using a target sequence identified by comparative genomic analysis. Int J Food Microbiol 2010; 137: 168-74.
[41]
Edelstein RL, Tamanaha CR, Sheehan PE, et al. The BARC biosensor applied to the detection of biological warfare agents. Biosens Bioelectron 2000; 14: 805-13.
[42]
Sun SH, Murray CB, Weller D, Folks L, Moser A. Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices. Science 2000; 287: 1989-92.
[43]
Liu Y, Miyoshi H, Nakamura M. Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. J Control Release 2006; 114: 89-99.
[44]
Yang J, Lee CH, Ko HJ, Suh JS, et al. Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer. Angew Chem Int 2007; 46: 8836-9.
[45]
Mitsumori M, Hiraoka M, Shibata T, et al. Development of intraarterial hyperthermia using a dextran-magnetite complex. Int J Hyperthermia 1994; 10: 785-93.
[46]
Roy I, Ohulchanskyy TY, Pudavar HE, et al. Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. J Am Chem Soc 2003; 125: 7860-5.
[47]
Huang X, Jain PK, El-Sayed IH, El-Sayed MA. Plasmonicphotothermal therapy (PPTT) using gold nanoparticles. Lasers Med Sci 2008; 23: 217-28.
[48]
Liu CJ, Wang CH, Chien CC, et al. Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification. Nanotechnology 2008; 19: 295104-9.
[49]
Tu SJ, Yang PY, Hong JH, Lo CJ. Quantitative dosimetric assessment for effect of gold nanoparticles as contrast media on radiotherapy planning. Radiat Phys Chem 2013; 88: 14-20.
[50]
Ma J, Wong H, Kong LB, Peng KW. Biomimetic processing of nanocrystalline bioactive apatite coating on titanium. Nanotechnology 2003; 14: 619-63.
[51]
Akiyama H, Ito A, Kawabe Y, Kamihira M. Fabrication of complex three-dimensional tissue architectures using a magnetic forcebased cell patterning technique. Biomed Microdevices 2009; 11: 713-21.
[52]
Morones JR, Elechiguerra JL, Camacho A, et al. The bactericidal effect of silver nanoparticles. Nanotechnology 2005; 16: 2346-53.
[53]
Zhao X, Toyooka T, Ibuki Y. Synergistic bactericidal effect by combined exposure to Ag nanoparticles and UVA458. Sci Total Environ 2013; 458-460: 54-62.
[54]
Šlouf M, Pavlova E, Bhardwaj M, et al. Preparation of stable Pd nanoparticles with tunable size for multiple immunolabeling in biomedicine. Mater Lett 2011; 65: 1197-200.
[55]
Mahtab R, Rogers JP, Murphy CJ. Protein-sized quantum-dot luminescence can distinguish between straight, bent, and kinked oligonucleotides. J Am Chem Soc 1995; 117: 9099-100.

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