Generic placeholder image

Current Nanomaterials

Editor-in-Chief

ISSN (Print): 2405-4615
ISSN (Online): 2405-4623

Research Article

Electrospun Ag/PMA Nanofibrous Scaffold as a Drug Delivery System

Author(s): Giulia Neri*, Salvatore Spadaro, Francesco Barreca, Saveria Santangelo, Fortunato Neri and Enza Fazio*

Volume 4, Issue 1, 2019

Page: [32 - 38] Pages: 7

DOI: 10.2174/2405461504666190416144047

Abstract

Background: Polymers play a key-role in the drug delivery technology. They allow for the controlled release of therapeutic agents under an external stimulus if a sensitive segment is suitable incorporated in the polymer matrix. Actually, polymer capsules containing noble metal nanostructures are regarded as promising light-responsive drug carriers. Among polymers, poly(methacrylic acid), PMA, offers manifold advantages: i) solubility in water, ii) coordination ability for Ag-Au nanoparticles, and iii) ability to act as capping agent. However, the preparation of Ag/PMA nanocolloids involves complex procedures the use of reagents with severe environmental impact.

Objective: The goal of this work is to develop Ag/PMA nanocolloids for the controlled release of the encapsulated therapeutic agent (Sorafenib Tosylate) through a simple and cost effective synthesis process and the use of biocompatible, implantable materials. The light- and heat-responsiveness of fibrous scaffolds of Ag/PMA nanocolloids produced by electrospinning is investigated and compared with that of Ag/PMA nanocolloids.

Methods: The goal of this work is to develop Ag/PMA nanocolloids for the controlled release of the encapsulated therapeutic agent (Sorafenib Tosylate) through a simple and cost effective synthesis process and the use of biocompatible, implantable materials. The light- and heat-responsiveness of fibrous scaffolds of Ag/PMA nanocolloids produced by electrospinning is investigated and compared with that of Ag/PMA nanocolloids.

Results: In both the investigated systems, Ag/PMA nanocolloids and electrospun scaffolds of Ag/PMA nanocolloids, the drug release is significantly favored by the considered stimuli. Upon heat stimulus, Ag/PMA nanocolloids provide greater cumulative drug release with respect to the electrospun scaffold. Conversely, upon light stimulus, the scaffold is able to release a larger amount of Sorafenib at a faster rate, thanks to the Ag-mediated laser irradiation heating effect.

Conclusion: The electrospun fibrous scaffold of Ag/PMA nanocolloids is demonstrated to be an efficient system for the remotely-triggered delivery of drug in a target area. The values of its loading efficiency (60%) and drug content (5.5%) are comparable to the ones obtained from amphiphilic copolymer structures prepared via complex chemical procedures with the use of toxic solvents and surfactant to stabilize the nanocolloids.

Keywords: Drug delivery, PMA, Ag nanoparticles, surface plasmon resonance, UV-enhanced chemical process, metalpolymeric colloids, stimuli-responsive scaffolds, electrospinning.

Graphical Abstract

[1]
Dahiya M, Dureja H. Recent developments in the formulation of nanoliposomal delivery systems. Curr Nanomater 2018; 3(2): 62-74.
[2]
Marturano V, Cerruti P, Giamberini M, Tylkowski B, Ambrogi V. Light-responsive polymer micro- and nano-capsules. Polymers 2017; 9: 8.
[3]
Compagnini G, Condorelli M, Fragalà M, et al. Growth kinetics and sensing features of colloidal silver nanoplates. J Nanomater 2019; 7084731: 8.
[4]
Fazio E, Scala A, Grimato S, Ridolfo A, Grassi G, Neri F. Laser light triggered smart release of Silibinin from a PEGylated-PLGA gold nanocomposite. J Mat Chem B 2015; 3: 9023-32.
[5]
Neri F, Scala A, Santoro M, et al. Biocompatible silver nanoparticles embedded in a PEG-PLA polymeric matrix for stimulated laser light drug release. J Nanopart Res 2016; 18: 153.
[6]
Suedee R. Novel strategic innovations for designing drug delivery system using molecularly imprinted micro/nanobeads. Int J Pharm Sci Rev Res 2013; 20: 235-68.
[7]
Ghafoor B, Aleem A, Ali MN, Mir M. Review of the fabrication techniques and applications of polymeric electrospun nanofibers for drug delivery systems. J Drug Deliv Sci Technol 2018; 48: 82-7.
[8]
Ding J, Zhang J, Li J, et al. Electrospun polymer biomaterials. Prog Polym Sci 2019; 90: 1-34.
[9]
Xue J, Xie J, Liu W, Xia Y. Electrospun nanofibers: new concepts, materials, and applications. Acc Chem Res 2017; 50: 1976-87.
[10]
Thenmozhi S, Dharmaraj N, Kadirvelu K, Kim HY. Electrospun nanofibers: new generation materials for advanced applications. Mater Sci Eng B 2017; 217: 36-48.
[11]
Zhang M, Zhao X, Zhang G, Wei G, Su Z. Electrospinning design of functional nanostructures for biosensor applications. J Mater Chem B 2017; 5: 1699-711.
[12]
Su Z, Ding J, Wei G. Electrospinning: a facile technique for fabricating polymeric nanofibers doped with carbon nanotubes and metallic nanoparticles for sensor applications. RSC Adv 2014; 4: 52598-610.
[13]
Cardenas G, Munoz C, Carbacho H. Thermal properties and TGA-FTIR studies of polyacrylic and polymethacrylic acid doped with metal clusters. Eur Polym J 2000; 36: 1091-9.
[14]
Dubas ST, Kumlangdudsana P, Potiyaraj P. Layer-by-layer deposition of antimicrobial silver nanoparticles on textile fibers. Colloids Surf A 2006; 289: 105-9.
[15]
He B, Tan JJ, Liew KY, Liu H. Synthesis of size controlled Ag nanoparticles. J Mol Catal 2004; 221: 121-6.
[16]
Saldias C, Bonardd S, Quezada C, Radic D, Leiva A. The role of polymers in the synthesis of noblemetal nanoparticles: a review. J Nanosci Nanotechnol 2016; 16: 1-28.
[17]
Spadaro D, Barletta E, Barreca F, Currò G, Neri F. PMA capped silver nanoparticles produced by UV-enhanced chemical process. Appl Surf Sci 2009; 255: 8403-8.
[18]
Spadaro D, Barletta E, Barreca F, Currò G, Neri F. Synthesis of PMA stabilized silver nanoparticles by chemical reduction process under a two-step UV irradiation. Appl Surf Sci 2010; 256: 3812-6.
[19]
Kissel M, Berndt S, Fiebig L, et al. Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma. Oncotarget 2017; 8(63): 107096-108.
[20]
Spadaro S, Santoro M, Barreca F, et al. PEG-PLGA elctrospun scaffolds loaded with Au@FeO nanoparticles for drug delivery applications. Front Phys 2018; 13(1): 9.
[21]
Zhao Y, Jiang Y, Fang Y. Spectroscopy property of Ag nanoparticles. Spectrochimica Acta A 2006; 65: 1003-6.
[22]
Mandal SK, Roy RK, Pal AK. Effect of particle shape distribution on the surface plasmon resonance of Ag–SiO2 nanocomposite thin films. J Phys D Appl Phys 2003; 36(3): 261.
[23]
Rentería VM, García–Macedo J. Influence of the local dielectric constant on modeling the optical absorption of silver nanoparticles in silica gels. J. Colloids Surf A Physicochem Eng Asp 2006; 278: 1-3.
[24]
Amoli-Diva M, Sadighi-Bonabi R, Pourghazi K. Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer. Mater Sci Eng C 2017; 76: 536-42.
[25]
Fathy M, Kashyout AB, El Nady J, Ebrahim Sh, Soliman MB. Electrospun polymethylacrylate nanofibers membranes for quasi-solid-state dye sensitized solar cells. Alexandria Eng J 2016; 55: 1737-43.
[26]
Biswal J, Misra N, Borde LC, Sabharwal S. Synthesis of silver nanoparticles in methacrylic acid solution by gamma radiolysis and their application for estimation of dopamine at low concentrations. Rad Phys Chem 2013; 83: 67-73.
[27]
Nishimura S, Mott D, Takagaki A, Maenosono S, Ebitani K. Role of base in the formation of silver nanoparticles synthesized using sodium acrylate as a dual reducing and encapsulating agent. Phys Chem Chem Phys 2011; 13: 9335-43.
[28]
Fong H, Chun I, Reneker DH. Beaded nanofibers formed during electrospinning. Polymer 1999; 40(16): 4585-92.
[29]
Li L, Peng S, Lee JKY, Ji D, Srinivasan M, Ramakrishna S. Electrospun hollow nanofibers for advanced secondary batteries. Nano Energy 2017; 39: 111-39.
[30]
Aruna ST, Balaji LS, Kumar SS, Prakash BS. Electrospinning in solid oxide fuel cells: a review. Renew Sust Energ Rev 2017; 67: 673-82.
[31]
Junoh H, Jaafar J, Norddin MNA, et al. A review on the fabrication of electrospun polymer electrolyte membrane for direct methanol fuel cell. J Nanomater 2015; 4: 16.
[32]
Li T, Ding X, Tian L, et al. The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs. Mater Sci Eng C 2017; 74(1): 471-7.
[33]
Liu Y, He JH, Yu JY, Zeng HM. Controlling numbers and sizes of beads in electrospun nanofibers. Polym Int 2008; 57: 632-6.
[34]
Deitzel JM, Kleinmeyer J, Harris D, Beck TNC. The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 2001; 42: 261-2.
[35]
Tong R, Tang L, Ma L, Tu C, Baumgartnerb R, Cheng J. Smart chemistry in polymeric nanomedicine. J Chem Soc Rev 2014; 43: 6982.
[36]
Jeong YI, Kim DH, Chung CW, et al. Doxorubicin-incorporated polymeric micelles composed of dextran-b-poly (DL-lactide-co-glycolide) copolymer. Int J Nanomed 2011; 6: 1415.
[37]
Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 2011; 3: 1377-97.

© 2024 Bentham Science Publishers | Privacy Policy