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Review Article

重编程的革命：小分子

卷 19, 期 2, 2019

页: [77 - 90] 页: 14

弟呕挨: 10.2174/1566524019666190325113945

价格: $65

摘要

从可及来源移植重编程细胞和体内重编程是再生医学的潜在疗法。在过去十年中，遗传方法（主要涉及转录因子和microRNA）已被证明会影响细胞命运。然而，它们潜在的致癌性和其他意想不到的影响限制了它们转化为临床应用。最近，凭借现代生物学设计和合成化学以及高通量筛选技术的力量，小分子已被证明可提高重编程效率，取代遗传因素，并有助于阐明细胞可塑性和退行性疾病的分子机制。 。作为一种非病毒和非整合方法，小分子不仅在产生所需的外源细胞类型方面具有革命性的能力，而且还具有通过修复或重编程内源细胞来恢复组织的药物的潜力。在这里，我们关注最近在细胞重编程中使用小分子的进展以及一些相关的机制来阐明这些问题。

关键词: 小分子，重编程，转分化，干细胞，再生医学，化学化合物。

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