摘要
背景和目的：D-二聚体促使纤维蛋白溶解系统参与阿尔茨海默病和2型糖尿病患者的并发症，特别是颈动脉斑块的患者。因此，本研究旨在探讨D-二聚体在2型糖尿病颈动脉斑块患者早期认知障碍中的作用。 方法：根据蒙特利尔认知评估评分，共招募175名中国2型糖尿病患者，分为两组。收集人口统计学数据，通过VIDAS D-二聚体测试血浆D-二聚体New，检查神经心理学测试，并通过超声检测颈动脉斑块，并进一步按脆弱性和水平分层。 结果：与健康认知控制相比，共有67名患有轻度认知障碍（MCI）的2型糖尿病患者血浆D-二聚体水平显着增加（p = 0.011）。血浆D-二聚体浓度与患有易损斑块的糖尿病患者（r = -0.471，p = 0.023）和具有稳定斑块的糖尿病患者的Stroop Color Word Test C（数量）的数字跨度测试评分呈负相关（r = -0.482， p <0.001）。多变量回归分析进一步显示D-二聚体浓度是糖尿病MCI伴颈动脉斑块的独立因素（p = 0.005），D-二聚体浓度尤其导致易患斑块的MCI高风险（p = 0.028）或高颈动脉斑块水平（p = 0.023）。 结论：D-二聚体水平升高可预测2型糖尿病患者颈动脉斑块，特别是易损斑块或高水平颈动脉斑块的早期认知功能障碍的高风险。
关键词: 颈动脉斑块，易损斑块，D-二聚体，纤维蛋白溶解系统，轻度认知障碍，2型糖尿病。
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