Interferon-α / β-Receptor Interactions: A Complex Story Unfolding

Title: Interferon-α / β-Receptor Interactions: A Complex Story Unfolding

Volume: 8 Issue: 24

Author(s): Raj Deonarain, David C.M. Chan, Leonidas C. Platanias and Eleanor N. Fish

Affiliation:

Keywords: interferon, ifnar1, ifnar2, binding residues

Abstract: The Type I interferons (IFN-α / ß) exhibit pleiotropic biological activities. Notably, the different IFN subtypes activate the same cell surface receptor complex to mediate variable responses. Accumulating evidence suggests that distinct differences in critical amino acid residues among the different IFN-αs and IFN-ß determine the nature of the ligand-receptor interaction and the subsequent responses. This review focuses on IFN-receptor interactions, the key residues involved in this interaction and the potential for targeted modifications of the ligand to enhance bioactivity.

Cite this article as:

Deonarain Raj, Chan C.M. David, Platanias C. Leonidas and Fish N. Eleanor, Interferon-α / β-Receptor Interactions: A Complex Story Unfolding, Current Pharmaceutical Design 2002; 8 (24) . https://dx.doi.org/10.2174/1381612023393288