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Research Article

地中海贫血主要诱导的骨质疏松症中的骨代谢标志物：来自横断面观察研究的结果

卷 19, 期 5, 2019

页: [335 - 341] 页: 7

弟呕挨: 10.2174/1566524019666190314114447

价格: $65

摘要

背景：重型地中海贫血（TM）患者最终面临许多新的健康状况，包括内分泌病和低骨密度，通常在老年人群中观察到。目的：本研究的目的是评估TM患者骨重建的生物标志物，并与骨质疏松症和健康人群进行比较，以探讨新的治疗途径。 方法：64名TM患者（32名男性和32名女性）参与了该研究。使用腰椎和股骨颈的双能X射线吸收测定法（DXA）和骨重建标志物评估患者，包括核因子κ-κB受体激活剂（RANKL），骨保护素（OPG），C-末端。端肽（CTX）和硬化蛋白。将结果与12名骨质疏松症绝经后妇女和12名骨密度正常的妇女进行比较。 结果：骨代谢的生化标志物的统计分析显示，仅RANKL和OPG / RANKL的三组之间存在总体显着差异（p = 0.049和p = 0.009）。与骨质疏松症组相比，TM患者的RANKL较高且OPG / RANKL较低。 结论：患有TM的患者患一般人群的骨质疏松症的可能性较高。然而，TM和骨质疏松症患者的破骨细胞活性的一些标志物不同，表明在抗骨质疏松症治疗方面可能存在差异。三组之间在CTX和硬化蛋白水平方面缺乏显着差异，这可能表明目前骨质疏松治疗对TM患者的潜在功效。

关键词: 骨质疏松症，重型地中海贫血，硬化蛋白，RANKL，OPG，内分泌病，骨代谢。

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