Login Register Cart 0
Generic placeholder image

Current Traditional Medicine

Editor-in-Chief

ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Antidiabetic Activity of the Methanolic Extracts of Thuja occidentalis Twings in Alloxan-induced Rats

Author(s): C.K. Tyagi, Pawan Porwal, Neeraj Mishra, Amit Sharma, A. Chandekar, R. Punekar, V.T. Punniyakoyi, Ajay Kumar and Durgadas Anghore*

Volume 5, Issue 2, 2019

Page: [138 - 143] Pages: 6

DOI: 10.2174/2215083805666190312153743

Price: $65

Abstract

Objective and Background: In hyperglycemic and alloxan-induced diabetic rats, the effect of Thuja occidentalis methanolic residue extract on blood glucose levels and some biochemical parameters were investigated.

Methods: Significantly decreased blood glucose level by 22.85% and 27.66%, in hyperglycemic rats, respectively after 3 h, were seen in a single oral administration of the extract at a dose of 200 and 400 mg/kg. Blood glucose level was decreased by 50% in alloxan-induced diabetic rats within three weeks of daily treatment of Thuja occidentalis methanolic residue extract (200 and 400 mg/kg p.o). Alloxan-induced diabetic rats showed significant hypercholesterolemia in comparison with the control in alloxan induced rats.

Results: In both normal and diabetic rats, there was also a significant decrease of elevated serum cholesterol and triglycerides. Hypertriglyceridemia was also shown to be prevented by treatment with plant extract (200 and 400mg/kg p.o) (p<0. 05). As compared with the control animals, diabetic control rats did not show any change in a level of creatinine and urea.

Conclusion: Thuja occidentalis treatment may improve glucose homeostasis in alloxaninduced diabetes and alleviate kidney and liver function. Thuja occidentalis twigs could be a potential source of the new oral antidiabetic drug.

Keywords: Thuja occidentalis, diabetes, alloxan, hyperglycemic activity, methanolic extracts, triglycerides.

Graphical Abstract

[1]
Zimmet PZ. Diabetes epidemiology as a tool to trigger diabetes research and care. Diabetologia 1999; 42(5): 499-518.
[2]
Sabo CE, Rush M, Temple LL. The use of alternative therapies by diabetic educators. Diabetes Educ 1999; 25: 945-56.
[3]
Diabetes Medicinal Plant Database (DiaMedBase) www.progenebio.in/DMP accessed on date August 24 . 2009.
[4]
Chang LC, Song LL, Park EJ, Luyengi L, Lee KJ, Norman R. Bioactive constituents of Thuja occidentais. J Nat Prod 2000; 63: 1235-8.
[5]
Namm SH, Kang MY. Antioxidant activity of medicinal plants. Pharm Biotechnol 2005; 42: 409.
[6]
Deb L, Dubey SK, Jain AK, Jain A, Pandian GS, Rout SP. Antidiarrhoeal activity of Thuja occidentalis Linn. ethanol extract on experimental animal. Indian Drugs 2007; 44: 319-21.
[7]
Belal N, Cornelia B, Martin T, Ulrike L. Thuja occidentalis (Arbor vitae): A review of its pharmaceutical, pharmacological and clinical properties. Advance Access Publication 2005; 2: 69-78.
[8]
Dongmin L, Wei Z, Zandong Y, Jeffery D. Genistein acutely stimulates insulin secretion in pancreatic β-cells through a cAMP-dependent protein kinase pathway. Diabetes 2006; 55: 1043-50.
[9]
Anghore D, Kulkarni GT. Development of novel nano niosomes as drug delivery system of Spermacoce hispida extract and in vitro antituberculosis activity. Curr Nanomater 2017; 2(1): 17-23.
[10]
Sezik E, Aslam M, Yesilada E, Ito S. Hypoglycemic activity of Gamtiana olivieri and isolation of active constituents through bioassay-directed fractionation techniques. Life Sci 2005; 76: 1223-38.
[11]
Babu V, Ganga DT, Subramonium A. Antihyperglycemic activity of Cassia kleinii leaf extract in glucose fed normal rats and alloxan induced diabetic rats. Indian J Pharmacol 2002; 34: 409-13.
[12]
Sabu MC, Subburaju T. Effect of Cassia auriculata linn. on serum glucose level, glucose utilization by isolated rat hemidiaphragm. J Ethnopharmacol 2002; 80(2-3): 203-6.
[13]
Jamal AA, Issa AA, Mohammad HH. Hypoglycaemic and antihyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J Ethnopharmacol 1997; 58: 149-55.
[14]
Phuong ML, Ali BA, Aziz E, Abdellatif S, Yahia C, Pierre SH. The petroleum ether extract of Nigella sativa exerts lipid lowering and insulin-sensitizing action in the rats. J Ethnopharmacol 2004; 94: 251-9.

Rights & Permissions Print Cite
Article Metrics
18
2
1
1
© 2024 Bentham Science Publishers | Privacy Policy