摘要
P-糖蛋白（P-gp）是ATP结合盒（ABC）转运蛋白家族的成员。由于其特有的腔表面位置，高运输效力和结构特异性，Pgp被认为是血脑屏障（BBB）的选择性守门人，以防止毒素或不需要的物质进入大脑。近年来，越来越多的证据表明，P-gp通过调节小胶质细胞激活和介导免疫细胞迁移参与中枢神经系统（CNS）疾病的免疫炎症反应。此外，糖皮质激素受体（GR）可能通过GR介导的mRNA衰变在P-gp介导的小胶质细胞激活和免疫细胞迁移中起关键作用。在本文中，我们将回顾P-gp的结构，分布，功能，调节机制，抑制剂和P-gp在几种中枢神经系统疾病发病机制中的作用，并将讨论P-gp在小胶质细胞激活，免疫细胞迁移和与细胞因子分泌的关系。
关键词: P-糖蛋白，中枢神经系统，免疫炎症，糖皮质激素受体，小胶质细胞，趋化因子（C-C基序）配体2。
图形摘要
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