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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

遗忘性轻度认知障碍的老年人睡眠的自然测量：焦虑症状不解释睡眠障碍

卷 16, 期 3, 2019

页: [233 - 242] 页: 10

弟呕挨: 10.2174/1567205016666190301104645

价格: $65

摘要

背景：睡眠障碍在阿尔茨海默病（AD）中很普遍。在遗忘性轻度认知障碍（aMCI）中，AD的临床前阶段，睡眠质量的恶化也被报道。然而，关于睡眠的哪些方面受到特征性影响，睡眠记录的设置是否影响这些发现，以及焦虑是否可以解释差异，缺乏共识。 目标：目前的研究旨在通过使用家庭内睡眠记录在自然环境中在aMCI中获得全面的睡眠测量来解决这些知识差距。 方法：17名健康老年人和12名患有aMCI的患者佩戴活动表两周，客观地记录习惯性睡眠模式，并完成两晚家庭内多导睡眠监测。 结果：在aMCI中，习惯性睡眠障碍在活动记录仪上很明显，包括睡眠发作后醒来后更多（p = .012，d = 0.99），碎片（p = .010，d = 1.03）和卧床时间（p = .046） ，d = .76）。虽然没有统计学意义，但多导睡眠监测对多导睡眠图产生了很大的影响，其中aMCI显示出比对照更慢的慢波睡眠（p> .05，d = .0.83）。在这项小型研究中，焦虑没有调节小组与睡眠之间的关系。 结论：结果表明，患有aMCI的人的睡眠质量比健康对照更差，这表明睡眠中断更多，慢波睡眠更少，即使在自然环境中也是如此。此外，焦虑症状不会调解这种关系。因此，该研究支持这样的观点，即睡眠障碍可能是aMCI中神经病理学变化的指征，而不是归因于心理因素。

关键词: 睡眠，阿尔茨海默病，轻度认知障碍，认知功能障碍，睡眠障碍，多导睡眠图，神经心理学，活动记录仪。

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