Generic placeholder image

Current Cardiology Reviews

Editor-in-Chief

ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

Hematological Parameters as Prognostic Biomarkers in Patients with Cardiovascular Diseases

Author(s): José Gildo de Moura Monteiro Júnior*, Dilênia de Oliveira Cipriano Torres and Dário Celestino Sobral Filho

Volume 15, Issue 4, 2019

Page: [274 - 282] Pages: 9

DOI: 10.2174/1573403X15666190225123544

Abstract

Cardiovascular diseases are the major causes of preventable health loss from disease in the world and lead to functional disturbances including hematological parameters. The inflammatory and hypoxemic nature of cardiovascular diseases causes a stimulus in the bone marrow and, depending on the intensity of this stimulus, there is a release of immature cells or increase of other cells in the bloodstream. Therefore, their presence in the circulation is an important variable used to diagnose, stratify and predict diseases.

In the last five decades, with the advent of automated counting of immature cells in the peripheral blood, the hemogram was transformed into a clinical tool of great importance in hospital surveillance for demonstrating this daily variability in the hematopoietic response according to the existing injury in the patient. Studies have shown that the presence of nucleated red blood cells and increases in mean platelet volume, immature granulocytes and neutrophil to lymphocyte ratio in the systemic circulation are independent prognostic biomarkers.

This review article has as main objective to demonstrate the association of these hematological parameters to cardiovascular diseases, emphasizing their importance in clinical decision making.

Keywords: Nucleated red blood cells, neutrophil to lymphocyte ratio, mean platelet volume, immature granulocytes, biomarkers, cardiovascular diseases.

Graphical Abstract

[1]
Thomas H, Diamond J, Vieco A, et al. Global atlas of cardiovascular disease 2000-2016: The path to prevention and control. Glob Heart 2018; 13(3): 143-63.
[2]
Li L, Xie W, Zheng X, Yin W, Tang C. A novel peptide adropin in cardiovascular diseases. Clin Chim Acta 2016; 453: 107-13.
[3]
Monteiro Júnior JGM, Torres DOC, Silva MCFC, et al. Nucleated red blood cells as predictors of all-cause mortality in cardiac intensive care unit patients: A prospective cohort study. PLoS One 2015; 10(12)e0144259
[4]
Verbrugge SE, Huisman A. Verification and standardization of blood cell counters routine clinical laboratory tests. Clin Lab Med 2015; (35): 183-96.
[5]
Fan L, Gui L, Chai EQ, Wei CJ. Routine hematological parameters are associated with short- and long-term prognosis of patients with ischemic stroke. J Clin Lab Anal 2018. Epub Ahead of Print
[6]
Söderholm M, Borné Y, Hedblad B, Persson M, Engström G. Red cell distribution width in relation to incidence of stroke and carotid atherosclerosis: A population-based cohort study. PLoS One 2015; 10(5)e0124957
[7]
Budziannowski J, Pieszko K, Burchardt P, Rzezniczak J, Hiczkiewicz J. The role of hematological indices in patients with acute coronary syndrome. Dis Markers 2017; 20173041565
[8]
Monteiro Júnior JGM, Torres DOC, da Silva MCFC, et al. Prognostic value of hematological parameters in patients with acute myocardial infarction: Intrahospital outcomes. PLoS One 2018; 13(4)e0194897
[9]
Wan G, Ji L, Xia W, Cheng L, Zhang Y. Screening genes associated with elevated neutrophiltolymphocyte ratio in chronic heart failure. Mol Med Rep 2018; 18(2): 1415-22.
[10]
Liu S, Wang P, Shen PP, Zhou JH. Predictive values of red blood cell distribution width in assessing severity of chronic heart failure. Med Sci Monit 2016; 22: 2119-25.
[11]
Emamian M, Hasanian SM, Tayefi M, et al. Association of hematocrit with blood pressure and hypertension. J Clin Lab Anal 2017; 31(6) Epub Ahead of Print
[12]
Enawgaw B, Adane N, Terefe B, Asrie F, Melku M. A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia. BMC Hematol 2017; 17: 21.
[13]
Weymann A, Ali-Hasan-Al-Saegh S, Popov AF, et al. Hematological índices as predictors of atrial fibrillation following isolated coronary artery by-pass grafting, valvular surgery or combined procedures: A systematic review with meta-analysis. Kardiol Pol 2018; 76(1): 107-18.
[14]
Musher DM, Abers MS, Corrales-Medina VF. Acute infection and myocardial infarction. N Engl J Med 2019; 380(2): 171-6.
[15]
Lecompte TP, Bernimoulin MP. Novel parameters in blood cell counters. Clin Lab Med 2015; (35): 209-24.
[16]
Guyton AC, Hall JE. Textbook of Medical Physiology, 11th edition editing in Portuguese by Elsevier 2006; ISBN 978-85-352-1641-7; 32: 419-28; 33:429-38; 36:. 457-68.
[17]
Machlus KR, Italiano JE Jr. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol 2013; 201(6): 785-96.
[18]
Green R, Wachsmann-Hogiu S. Development, history, and future of automated cell counters. Clin Lab Med 2015; 35(1): 1-10.
[19]
Stachon A, Sebbers E, Holland-Letz T, Kempf R, Herinf S, Krieg M. Nucleated red blood cells in the blood of medical intensive care patients indicate increased mortality risk: A prospective cohort study. Crit Care 2007; 11: R62.
[20]
Desai S, Jones SL, Turner KL, Hall J, Moore LJ. Nucleated red blood cells are associated with a higher mortality rate in patients with surgical sepsis. Surg Infect 2012; 13(6): 360-5.
[21]
Kuert S, Holland-Letz T, Friese J. stachon A. association of nucleated red blood cells in blood and arterial oxygen partial tension. Clin Chem Lab Med 2011; 49(2): 257-63.
[22]
Felker GM, Allen LA, Pocock SJ, et al. Red distribution width as a novel prognostic marker in heart failure. J Am Coll Cardiol 2007; 50(1): 40-7.
[23]
Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117(2): 163-8.
[24]
Baskurt OK, Meiselman HJ. Erythrocyte aggregation: Basic aspects and clinical importance. Clin Hemorheol Microcirc 2013; 53(1-2): 23-37.
[25]
Ami RB, Barshtein G, Zeltser D, et al. Parameters of red blood cell aggregation as correlates of the inflammatory state. Am J Physiol Heart Circ Physiol 2001; 280(5): H1982-8.
[26]
Tikhomirova IA, Oslyakova AO, Mikhailova SG. Microcirculation and blood rheology in patients with cerebrovascular disorders. Clin Hemorheol Microcirc 2011; 49: 295-395.
[27]
Koscielny J, Jung EM, Mrowietz C, Kiesewetter H, Latza R. Blood fluidity, fibrinogen, and cardiovascular risk factors of occlusive arterial disease: Results of the Aachen study. Clin Hemorheol Microcirc 2004; 31(3): 185-95.
[28]
Packard RRS, Libby P. Inflamation in atherosclerosis: From vascular biology to biomarker discovery and risk prediction. Clin Chem 2008; 54(1): 24-38.
[29]
Zazula AD, Précoma-Neto D, Gomes AM, et al. Avaliação da relação neutrófilos/linfócitos em pacientes com suspeita de síndrome coronariana aguda. Arq Bras Cardiol 2008; 90(1): 31-6.
[30]
Association between the Neutrophil / Lymphocyte Ratio and the Degree of Electrocardiographic Ischemia in the STEMI. Arq Bras Cardiol 2015; 104(2): 112-9.
[31]
Núñez J, Núñez E, Bodí V, et al. Low lymphocyte count in acute phase of ST-segment elevation myocardial infarction predicts long-term recurrent myovardial infarction. Coron Artery Dis 2010; 21: 1-7.
[32]
Basem A, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short and long-term mortality after non-ST elevation myocardial infarction. Am J Cardiol 2010; 106(4): 470-6.
[33]
Uysal HB, Dagli B, Akgullu C, et al. Blood count parameteres can predict the severity of coronary artery disease. Korean J Intern Med 2016; 31: 1093-100.
[34]
Verdoia M, Barbieri L, Di Giovine G, et al. Neutrophil to lymphocyte ratio and the extent of coronary artery disease: Results from a large cohort study. Angiology 2016; 67(1): 75-82.
[35]
Kaya H, Ertas F, Islamoglu Y, et al. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clin Appl Thromb Hemost 2014; 20(1): 50-4.
[36]
Larsen SB, Grove EL, Hvas AM, Kristensen SD. Platelet turnover in stable coronary artery disease – influence of thrombopoietin and low-grade inflamation. PLoS One 2014; 9(1)e85566
[37]
Grove EL, Hvas AM, Mortensen SB, Larsen SB, Kristensen SD. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Hemost 2011; 9: 185-91.
[38]
Wendland AE, Farias MG, Manfroi WC. Volume plaquetário médio e doença cardiovascular. J Brasileiro Patologia Medicina Laboratorial 2009; 45(5): 371-8.
[39]
Puertas M, Zayas-Castro JL, Fabri PJ. Statiscal and prognostic analysis of dynamic changes of platelet count in ICU patients. Physiol Meas 2015; 36: 939-53.
[40]
Greinacher A, Selleng K. Thrombocytopenia in the intensive care unit patient. Hematology 2010; 2010: 135-43.
[41]
Labriolle AD, Bonello L, Lemesle G, et al. Decline in platelet count in patients treated by percutaneous coronary intervencion: Defition, incidence, prognostic importance, and predictive factors. Eur Heart J 2010; 31(9): 1079-87.
[42]
Monteiro Júnior JGM, Torres DOC, Silva MCFC, et al. Evaluation of platelet parameters as prognostic analysis in cardiac intensive care units patients. Atherosclerosis 2017; 2: 1.
[43]
Murat SN, Duran M, Kalay N, et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology 2013; 64(2): 131-6.
[44]
Klovaite J, Benn M, Yazdanyar S, Nordestgaard BG. High platelet volume and increased risk of myocardial infarction: 39,531 participants from the general population. J Thromb Hemost 2011; 9(1): 49-56.
[45]
Ibrahim H, Schutt RC, Hannawi B, DeLao T, Barker CM, Kleiman NS. Association of immature platelets with adverse cardiovascular outcomes. J Am Coll Cardiol 2014; 2014: 2122-9.
[46]
Bernlochner I, Goedel A, Plischke C, et al. Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome. Eur Heart J 2015; 36: 3202-10.
[47]
Grove EL, Hvas AM, Mortensen SB, Larsen SB, Kristensen SD. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011; 9: 185-91.
[48]
Buttarello M, Plebani M. Automated blood cell counts: State of the art. Am J Clin Pathol 2008; 130(1): 104-16.
[49]
Ansari-Lari MA, Kickler TS, Borowitz MJ. Immature granulocyte measurement using the Sysmex XE-2100. Relationship to infection and sepsis. Am J Clin Pathol 2003; 120(5): 795-9.
[50]
Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: Internacional guidelines for management of severe sepsis and septic shock 2012. Intensive Care Med 2013; 39(2): 165-228.

© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version310msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[17:55:00] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[17:55:00] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[17:55:00] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (97.14ms)time
  • Application (213ms)time
  • 1 x Application (68.68%)
    213ms
    1 x Booting (31.32%)
    97.14ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    32 statements were executed, 4 of which were duplicates, 28 unique. Show only duplicated148ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314520269','',1,1739987700,1739987700) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739987700
      910μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314520269','/article/96845',1,1739987700,1739987700)
      140μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314520269 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314520269) limit 1
      11.08msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314520269
      • 1: 314520269
      • 2: 314520269
      • 3: 314520269
      • 4: 314520269
      • 5: 314520269
      • 6: 314520269
      • 7: 314520269
      • 8: 314520269
      • 9: 314520269
      • 10: 314520269
      • 11: 314520269
      • 12: 314520269
      • 13: 314520269
      • 14: 314520269
      • 15: 314520269
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=96845
      600μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 16 limit 1
      670μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 16
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=16) and sj.journal_id!=16 group by `j`.`nid`) as `aggregate_table`
      510μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=16) and sj.journal_id!=16 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      440μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=16) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      740μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=16) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      810μsalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '96845'
      260μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 96845
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '96845'
      2.14msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 96845
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '96845' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.51msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 96845
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 16 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      24.81msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 16 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      4.83msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 16 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      3.65msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 96845 limit 1
      200μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 96845
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 96845 and content_type = 'article' order by status desc limit 1
      810μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 258 and cd.sub_disease_id = 299 and content_id!=96845 and cd.content_type = 'article' order by rand() limit 20
      85.73msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 170202 limit 1
      210μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 170202
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      200μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CCR' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      230μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CCR
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '96845' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      330μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '274' and is_uploaded = 1 and issue_id = 9260 order by cast(first_page as SIGNED) desc limit 1
      420μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 274
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '282' and is_uploaded = 1 and issue_id = 9260 order by cast(first_page as SIGNED) asc limit 1
      380μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 282
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      150μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      170μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 96845 limit 1
      2.34msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 96845
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 16 and `b`.`banner_from_date` <= 1739987700 and `b`.`banner_to_date` >= 1739987700 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 16
      • 3: 1739987700
      • 4: 1739987700
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 16 and `b`.`banner_from_date` <= 1739987700 and `b`.`banner_to_date` >= 1739987700 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.08msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 16
      • 3: 1739987700
      • 4: 1739987700
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='e87cff3db0588cfe62dd9bf325c40140'
      190μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        IZSDeeT4ehIeqhYXKjBnFKSH3LlIg47RloPU8mzW
        uc_cart_id
        e87cff3db0588cfe62dd9bf325c40140
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/96845" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/96845
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6InNuYVprME1OR1ArWFdnMTQwNWUvZnc9PSIsInZhbHVlIjoiU0w0aDZNK3FET3ZWeHBqZURmeWxYR0Z0OTJSVU9maTlaU1lIdEltbHNCQT0iLCJtYWMiOiI4MDhmODY4OWViYWYxYjJlMjlmNWI5MDUwOWJmYTMzZTQ2YWZkYWZmMmIwYjU5MDA5ODEyNjFiYzZlZWEwNDI5IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6InNuYVprME1OR1ArWFdnMTQwNWUvZnc9PSIsInZhbHVlIjoiU0w0aDZNK3FET3ZWeHBqZURmeWxYR0Z0OTJSVU9maTlaU1lIdEltbHNCQT0iLCJtYWMiOiI4MDhmODY4OWViYWYx" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 17:55:00 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik5kMGIxUTc3V1M1ZlJDQlo2MVgyN3c9PSIsInZhbHVlIjoiV2Q0cXpJVzBFU3F5MGN4QU9YeStCRS9GQkVFQ250Wm5tNC9XL00vekpXamJQMUdpcnN1OG9HajlmcG0yc1c0bGNXbE1RTmlKOVJtdWpVTzNtUGVFZmp0MUgxb0VkMGk0NFdabm0zZjZvWUwyZURWM0dkZXZHbzVYZUphaUhYbFgiLCJtYWMiOiJkZDg2NjBjZjYyYjZiYWJkMjJjZDRjNzFjZGJlOTA3NGM0ZThmNzI2MjQxYTY0NmQ0YWRhMjBkZWRmZGI4M2Y2IiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 05:55:00 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Ik5kMGIxUTc3V1M1ZlJDQlo2MVgyN3c9PSIsInZhbHVlIjoiV2Q0cXpJVzBFU3F5MGN4QU9YeStCRS9GQkVFQ250Wm5tNC9XL00vekpXamJQMUdpcnN1OG9HajlmcG0yc1c0bGNXbE1RT" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ind0Y29ISFB1ai9IOHE1TGJDTGFLVWc9PSIsInZhbHVlIjoiT0ZaeEVCL1BtekFodCtwWmRqTFZNYlZ1aVJkWmdQMjBFcjJrU1dOdGVERXNvSDY1c0NyeUJEZmZVejlpQVdpcEdCVVJ6YWtLclFzZ2xDYWlmQmV5R0szcXpBUXpxb3JEV0pjRVROOVpESzZYMWxTYkJjVFlzTlpaM0x6bmdkeE0iLCJtYWMiOiJiNjBkYWQwMGI4NWU3OTNmNjE5MDIzNGJmMzY3NWExNTBjNDdmMzkzZDk4ZDAzNDEyNTlkZTY2N2IzMjAyZDMyIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ind0Y29ISFB1ai9IOHE1TGJDTGFLVWc9PSIsInZhbHVlIjoiT0ZaeEVCL1BtekFodCtwWmRqTFZNYlZ1aVJkWmdQMjBFcjJrU1dOdGVERXNvSDY1c0NyeUJEZmZ" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Ik5kMGIxUTc3V1M1ZlJDQlo2MVgyN3c9PSIsInZhbHVlIjoiV2Q0cXpJVzBFU3F5MGN4QU9YeStCRS9GQkVFQ250Wm5tNC9XL00vekpXamJQMUdpcnN1OG9HajlmcG0yc1c0bGNXbE1RTmlKOVJtdWpVTzNtUGVFZmp0MUgxb0VkMGk0NFdabm0zZjZvWUwyZURWM0dkZXZHbzVYZUphaUhYbFgiLCJtYWMiOiJkZDg2NjBjZjYyYjZiYWJkMjJjZDRjNzFjZGJlOTA3NGM0ZThmNzI2MjQxYTY0NmQ0YWRhMjBkZWRmZGI4M2Y2IiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 05:55:00 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Ik5kMGIxUTc3V1M1ZlJDQlo2MVgyN3c9PSIsInZhbHVlIjoiV2Q0cXpJVzBFU3F5MGN4QU9YeStCRS9GQkVFQ250Wm5tNC9XL00vekpXamJQMUdpcnN1OG9HajlmcG0yc1c0bGNXbE1RT" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ind0Y29ISFB1ai9IOHE1TGJDTGFLVWc9PSIsInZhbHVlIjoiT0ZaeEVCL1BtekFodCtwWmRqTFZNYlZ1aVJkWmdQMjBFcjJrU1dOdGVERXNvSDY1c0NyeUJEZmZVejlpQVdpcEdCVVJ6YWtLclFzZ2xDYWlmQmV5R0szcXpBUXpxb3JEV0pjRVROOVpESzZYMWxTYkJjVFlzTlpaM0x6bmdkeE0iLCJtYWMiOiJiNjBkYWQwMGI4NWU3OTNmNjE5MDIzNGJmMzY3NWExNTBjNDdmMzkzZDk4ZDAzNDEyNTlkZTY2N2IzMjAyZDMyIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ind0Y29ISFB1ai9IOHE1TGJDTGFLVWc9PSIsInZhbHVlIjoiT0ZaeEVCL1BtekFodCtwWmRqTFZNYlZ1aVJkWmdQMjBFcjJrU1dOdGVERXNvSDY1c0NyeUJEZmZ" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "IZSDeeT4ehIeqhYXKjBnFKSH3LlIg47RloPU8mzW" "uc_cart_id" => "e87cff3db0588cfe62dd9bf325c40140" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/96845" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 17:55:00GET/article/96845314321