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Review Article

靶向DNA双链断裂（DSB）修复以抵抗肿瘤放射抗性

卷 20, 期 9, 2019

页: [891 - 902] 页: 12

弟呕挨: 10.2174/1389450120666190222181857

价格: $65

摘要

在过去十年中，在癌症治疗的临床实践中已经进行了放射疗法（RT）的进展。 RT主要通过导致DNA双链断裂（DSB）发挥其抗癌作用，这是DNA毒性最大的DNA损伤之一。非同源末端连接（NHEJ）和同源重组（HR）是人细胞中的两种主要DSB修复途径。已知DSB修复的失调引起癌症的易感性并且可能导致对包括RT在内的癌症疗法的抗性。因此，针对DSB修复提出了一种抵消无线电阻抗的有吸引力的策略。在这篇综述中，我们描述了两种DSB修复途径的最新知识，重点介绍了几种有助于修复的关键蛋白，如DNA-PKcs，RAD51，MRN和PARP1。最重要的是，我们通过将这些蛋白质作为治疗抑制剂来讨论克服抗辐射性的可能性。最近对实验室中DSB修复抑制剂的测试及其在临床研究中的翻译也得到了解决。

关键词: DNA双链断裂修复，放射治疗，放射抗性，放射增敏剂，分子靶向，联合治疗。

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