Abstract
Background: Applying of "double-drug" strategy to 5-nitrofuran derivatives has been proposed.
Methods: A small library of 5-Nitrofuran-2-yl Thiohydrazones was developed, and initial screening demonstrated good activity against bacteria and fungi of ESKAPE panel.
Results and Conclusion: The synthesis of the desired thiohydrazones was carried out via condensation of 5-nitrofuran-2-carbaldehyde with thiohydrazides of substituted oxamic acids.
Keywords: 5-Nitrofuran derivatives, thiohydrazones, double drug, health care-associated infections, bacterial resistance, CO-ADD.
Graphical Abstract
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