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Drug Delivery Letters

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ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

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Research Article

Formulation and Evaluation of Polymeric Nanomicelles of Gliptin for Controlled Drug Delivery

Author(s): Deepika Sharma and Bhavna Kumar*

Volume 9, Issue 2, 2019

Page: [146 - 156] Pages: 11

DOI: 10.2174/2210303109666190212112505

Price: $65

Abstract

Objective: The main objective of the study was to develop gliptin loaded polymeric nanomicelles by direct dissolution method. The comparative evaluation studies were performed to study the effect of polymer concentration on particle size, entrapment efficiency, loading capacity and drug release of the formulation.

Methods: Gliptin loaded polymeric nanomicelles were prepared by the direct dissolution method. The formulations were prepared by varying the concentration of polymer and drug concentration was kept constant in all the formulations. The concentration of polymer (pullulan) was maintained 0.1%, 0.5% 1% in formulation F-1, F-2 and F-3, respectively. The effect of polymer concentration on mean particle size, zeta potential, % entrapment efficiency, % loading capacity and in vitro drug release was studied.

Results: The optimized nanoformulation was obtained with pullulan 0.1% concentration with a mean particle diameter of 368.2nm and zeta potential value (-7.96mV) indicating greater stability.

Conclusion: Hence F-1 was considered to be the best formulation for the preparation of gliptin loaded polymeric nanomicelles. Hence, it can be concluded that polymeric nanomicellar approach can be beneficial to improve the bioavailability and poor permeability of class III drugs like gliptins and thus can be a better approach for controlled drug delivery.

Keywords: Gliptin, pullulan, polymeric nanomicelles, controlled drug delivery, mean particle size, zeta potential.

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[1]
Seshadri, G.K.; Kirubha, B.M. Gliptins: A new class of oral antidiabetic agents. Indian J. Pharm. Sci., 2009, 71(6), 608-614.
[2]
Roseman, T.J.; Cardinelli, N.F. In controlled release technologies (Kydonieus AFeds); Boca Raton : CRC Press, 1980.
[3]
Gallwitz, B. Review of sitagliptin phosphate: A novel treatment for type 2 diabetes. Vasc. Health Risk Manag., 2007, 3(2), 203-210.
[4]
Kedar, U.; Phutane, P.; Shidhaye, S.; Kadam, V. Advances in polymeric micelles for drug delivery and tumor targeting. Nanomedicine, 2010, 6(6), 714-729.
[5]
Witharana, C.; Wanigasekara, J. Applications of nanotechnology in drug delivery and design - an insight. Curr. Trends Biotechnol. Pharm., 2016, 10(1), 78-91.
[6]
Ghadiri, M.; Farahani, V.E.; Atyabi, F.; Kobarfard, F. Transferrin‐conjugated magnetic dextran‐spermine nanoparticles for targeted drug transport across blood‐brain barrier. J. Biomed. Mater. Res. A, 2017, 105(10), 2851-2864.
[7]
Azzam, T.; Eliyahu, H.; Shapira, L. Polysaccharide−oligoamine based conjugates for gene delivery. J. Med. Chem., 2002, 45(9), 1817-1824.
[8]
Alibolandi, M.; Abnous, K.; Sadgehi, F. Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: In vitro and in vivo evaluation. Int. J. Pharm., 2016, 500(1-2), 162-178.
[9]
Mottaghitalab, F.; Farokhi, M.; Shokhrgozar, M.A. Silk fibroin nanoparticle as a novel drug delivery system. J. Control. Release, 2015, 206, 161-176.
[10]
Alibolandi, M.; Abnous, K.; Ramezani, M. Synthesis of AS1411-aptamer-conjugated CdTe quantum dots with high fluorescence strength for probe labeling tumor cells. J. Fluoresc., 2014, 24(5), 1519-1529.
[11]
Chiang, C.H.; Hosseinkhani, H.; Cheng, W.S.; Chen, C.W.; Wang, C.H.; Lo, Y.L. Improving drug loading efficiency and delivery performance of micro- and nanoparticle preparations through optimising formulation variables. Int. J. Nanotechnol., 2013, 10(10/11), 996-1006.
[12]
Cholkar, K.; Patel, A.; Vadlapudi, A.D.; Mitra, A. Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery. Recent Pat. Nanomed., 2012, 2(2), 82-95.
[13]
Vaishya, D.R.; Khurana, V.; Patel, S.; Mitra, K.A. Controlled ocular drug delivery with nanomicelles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2014, 6(5), 422-437.
[14]
Singh, R.S.; Saini, G.K.; Kennedy, J.F. Pullulan: Microbial sources, production and applications. Carbohyd. Polym., 2008, 73, 515-520.
[15]
Kumar, D.; Saini, N.; Pandit, V.; Ali, S. An insight to pullulan: A biopolymer in pharmaceutical approach. Int. J. Basic Appl. Sci., 2012, 1, 202-219.
[16]
Hassanzadeh, F.; Varshosaz, J.G.; Khodarahmi, A.; Mahboubeh, R. Biotin-encoded pullulan-retinoic acid engineered nanomicelles: Preparation, optimization and in vitro cytotoxicity assessment in mcf-7 cells. Indian J. Pharm. Sci., 2016, 78(5), 557-565.
[17]
Cui, F.; Qian, F.; Yin, C. Preparation and characterization of mucoadhesive polymer-coated nanoparticles. Int. J. Pharm., 2006, 316(1-2), 154-161.
[18]
Bowman, K.; Leong, W.K. Chitosan nanoparticles for oral drug and gene delivery. Int. J. Nanomedicine, 2006, 1(2), 117-128.
[19]
Sutar, P.S.; Joshi, V.G. Gemcitabine loaded plga nanoparticles- an approach for colorectal cancer. Univer. J. Pharm., 2013, 02(05), 135-141.
[20]
Chauhan, C.S.; Udawat, H.S.; Naruka, P.S.; Chouhan, N.S.; Meena, M.S. Micellar solubilization of poorly water soluble drug using non ionic surfactant. Int. J. Advan. Res. Pharm. Bioscien., 2012, 2(1), 1-8.
[21]
Lamoudi, L.; Chaumeil, C.J.; Daoud, K. PLGA nanoparticles loaded with the non-steroid anti-inflammatory: Factor influence study and optimization using factorial design. Int. J. Chem. Eng. Appl., 2013, 4(6), 369-372.
[22]
Reddy, A.S.; Sailaja, A.K. Preparation and characterisation of aspirin loaded ethylcellulose nanoparticles by solvent evaporation technique. J. Pharm. Pharm. Sci., 2014, 3(6), 1781-1793.
[23]
Torchilin, V.P. Structure and design of polymeric surfactant-based drug delivery systems. J. Control. Release, 2001, 73(2-3), 137-172.
[24]
Kwon, G.S.; Kataoka, K. Block copolymer micelles as long circulating drug vehicles. Adv. Drug Delivery. Rev., 1995, 16(2), 295-299.
[25]
Jones, M. Leroux, J. Polymeric micelles- a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm., 1999, 48(2), 101-111.

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