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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

Author(s): Christopher G. Adda, Robin F. Anders, Leann Tilley and Michael Foley

Volume 5, Issue 1, 2002

Page: [1 - 14] Pages: 14

DOI: 10.2174/1386207023330561

Price: $65

Abstract

Phage display has become a widely used tool for the identification of proteins or peptides with affinity for a variety of biomolecules. The versatility, simplicity and cost effectiveness of this application has pervaded a wide variety of research areas. Although not without its limitations, phage display has provided a convenient methodology for obtaining ligands to study the function, structure and diagnostic or therapeutic potential of various macromolecules. This review highlights some recent research employing this technology that serves to illustrate its utility in various research and clinical applications.

Keywords: Phage display, biopannig, tissue-type plasminogen activator

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