摘要
基因工程和基因组研究的进展促进了人类疾病动物模型的发展。迄今为止,许多基于不同动物种类的模型可用于最具社会意义的人类疾病,如心血管疾病、癌症、神经退行性和代谢性疾病。现代的基因方法可以创造出某些基因上调或下调的动物,也可以产生特定的突变。然而,这种精确性不容易转化为临床实践:动物模型仍然有其局限性,包括人与动物之间的生理和遗传差异以及难以复制的疾病条件的复杂性。在这篇综述中,我们将讨论最相关的现代技术,允许创建基因工程动物模型。
关键词: 基因编辑,基因工程,动物模型,CRISPR,人类疾病,1号染色体。
Current Molecular Medicine
Title:Human Disease Modelling Techniques: Current Progress
Volume: 18 Issue: 10
关键词: 基因编辑,基因工程,动物模型,CRISPR,人类疾病,1号染色体。
摘要: Advances in genetic engineering and genomic studies facilitated the development of animal models of human diseases. To date, numerous models based on different animal species are available for the most socially significant human diseases, such as cardiovascular disorders, cancer, neurodegenerative and metabolic disorders. Modern genetic methods allow creating animals with certain genes up- or downregulated, as well as bearing specific mutations. However, this precision is not easy to translate into clinical practice: animal models still have their limitations, including both physiological and genetic differences between humans and animals and complexity of disease conditions that are difficult to reproduce. In this review, we will discuss the most relevant modern techniques that allow creating genetically engineered animal models.
Export Options
About this article
Cite this article as:
Human Disease Modelling Techniques: Current Progress, Current Molecular Medicine 2018; 18 (10) . https://dx.doi.org/10.2174/1566524019666190206204357
DOI https://dx.doi.org/10.2174/1566524019666190206204357 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Applications of Mesoporous Materials as Excipients for Innovative Drug Delivery and Formulation
Current Pharmaceutical Design Combination of Anti-EGFR Drugs with Anti-Angiogenic or Other Signal Transduction Inhibitors as a Rational Approach to Cancer Therapy
Current Cancer Therapy Reviews Structure of the Epidermal Growth Factor Receptor Gene and Intron Recombination in Human Gliomas
Current Genomics Tumor-Receptor Imaging in Breast Cancer: A Tool for Patient Selection and Response Monitoring
Current Molecular Medicine Anti-Vascular Endothelial Growth Factor (VEGF) Therapy: A New Cause of Hypertension
Current Hypertension Reviews Synthesis of 2-substituted Furo[3,2-b]pyridines Under Pd/C-Cu Catalysis Assisted by Ultrasound: Their Evaluation as Potential Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry Green Reduction of Graphene Oxide into Graphene by Cow Urine
Current Nanomaterials Recent Patents for Homologous Recombination Deficiency Assays Among Women with Ovarian Cancer
Recent Patents on Biotechnology Withdrawal Notice: EnzyPha, an Engineered Helper Phage Developed to Overcome Most of the Limitations Regarding Filamentous Phage Titration and ELISA Tests
Protein & Peptide Letters Molecular Processes in Cancers and Cancer Chemotherapy
Current Chemical Biology Natural and Nanotechnology Based Treatment: An Alternative Approach to Psoriasis
Current Nanomedicine Evaluation of BMP-2 Minicircle DNA for Enhanced Bone Engineering and Regeneration
Current Gene Therapy Targeted Delivery of Lipid Nanoparticles by Means of Surface Chemical Modification
Current Organic Chemistry Biomarkers for Systemic Therapy in Ovarian Cancer
Current Cancer Drug Targets Immunomodulatory Effect of Probiotic Bacteria
Recent Patents on Inflammation & Allergy Drug Discovery Anti-cancer Effects of Curcumin on Head and Neck Cancers
Anti-Cancer Agents in Medicinal Chemistry Utility of Assessing Thiopurine S-methyltransferase Polymorphisms Before Azathioprine Therapy
Current Drug Metabolism Adenoid Cystic Carcinoma of the Breast
Current Medical Imaging The Epidermal Growth Factor Receptor as a Therapeutic Target in Glioblastoma Multiforme and other Malignant Neoplasms
Anti-Cancer Agents in Medicinal Chemistry Vitamin D Analogs as Modulators of Vitamin D Receptor Action
Current Topics in Medicinal Chemistry