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Review Article

基于癌症干细胞抗原特性的癌症免疫治疗新方法

卷 19, 期 1, 2019

页: [2 - 11] 页: 10

弟呕挨: 10.2174/1566524019666190204114721

价格: $65

摘要

背景：癌症干细胞（CSC）是一种罕见的肿瘤细胞群，在肿瘤的发生，发展和维持中起重要作用。大约150年前提出了癌细胞来自干细胞的概念。最近，考虑到肿瘤细胞的异质性，该假设得到了更新。 CSC对化疗和放射治疗有抵抗力。因此，靶向CSC可能是一种与肿瘤细胞作斗争的新颖有效的策略。 目的：在这篇小型综述中，我们强调不同的免疫治疗方法可用于靶向癌细胞和根除不同的肿瘤细胞。最重要的靶标是在CSC表面上识别为CSC抗原的特异性标记，例如CD44，CD133，醛脱氢酶（ALDH）和SOX家族成员。本文强调了癌症治疗中CSCs的最新进展。 结果：我们的结果表明CSC抗原在肿瘤起始中起重要作用，特别是在对化学和放射治疗剂有抗性的细胞中。因此，它们是癌症免疫疗法的理想靶标，例如，开发不同类型的癌症疫苗或针对肿瘤细胞的抗体。 结论：简要总结了目前通过基于CSC抗原的特性靶向CSC抗原进行癌症免疫治疗的研究。总之，CSC抗原可以有效地靶向治疗癌症患者。

关键词: 癌症干细胞抗原，癌症免疫疗法，异质性，靶标，肿瘤细胞，干细胞。

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