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Current Analytical Chemistry

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ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

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Review Article

Advances in Chiral Separations at Nano Level

Author(s): Al Arsh Basheer, Iqbal Hussain, Marcus T. Scotti, Luciana Scotti and Imran Ali*

Volume 16, Issue 4, 2020

Page: [351 - 368] Pages: 18

DOI: 10.2174/1573407215666190131122413

Price: $65

Abstract

Background: Nano level chiral separation is necessary and demanding in the development of the drug, genomic, proteomic, and other chemical and the environmental sciences. Few drugs exist in human body cells for some days at nano level concentrations, that are out of the jurisdiction of the detection by standard separation techniques. Likewise, the separation and identification of xenobiotics and other environmental contaminants (at nano or low levels) are necessary for our healthiness.

Discussion: This review article reports the state-of-the-art of nano level chiral analyses by nano liquid chromatography (NLC) and nano capillary electrophoresis (NCE). The optimization procedure of the enantiomeric resolution is also deliberated. Also, the efforts are made to describe the chiral resolution mechanisms of in NLC and NCE. Finally, the future perspectives are also emphasized.

Conclusion: This article will be beneficial for chiral chromatographers, academicians, pharmaceutical industries, environmental researchers and Government regulation authorities.

Keywords: Chiral recognition mechanisms, drug, enantioseparation, genomic, nano capillary electrophoresis, nano liquid chromatography, proteomic.

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Graphical Abstract

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