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Review Article

治疗偏头痛的天然产物及其(半)合成形式:历史和现状

卷 27, 期 23, 2020

页: [3784 - 3808] 页: 25

弟呕挨: 10.2174/0929867326666190125155947

价格: $65

摘要

背景: 偏头痛可被描述为伴有中度至极度疼痛的头痛，常伴有神经功能障碍症状。据估计，世界人口的12%患有偏头痛。虽然已经有一些药物用于治疗偏头痛，但大多数药物并不是对每个患者都有效，而且可能会产生不良的副作用。因此，在目前的偏头痛治疗中，发现更安全和更有效的药物是一个巨大的需求。 方法:通过广泛的文献查阅和检索相关书籍和文章，并利用Web of Knowledge和SciVerse Scopus数据库，来获取本综述的信息。 结果: 对偏头痛发病机制的分子机制有更深入的了解，有助于识别新的抗偏头痛药物的靶点，如大麻素、组胺和褪黑素受体。在过去，天然产物衍生的成分是许多具有药用价值的抗偏头痛药物的宝贵来源，可以预估：将会从天然产物中发现更多有前景的用于抗偏头痛药物治疗的候选药物，其疗效更好，副作用更少。 结论: 偏头痛治疗中新靶点的发现为未经过临床试验或以前在临床试验中失败的潜在抗偏头痛药物打开了新视野。银杏内酯B、褪黑素、组胺、催产素、各种核糖体肽毒素、卡瓦内酯、魔鬼爪衍生化合物、salvinorin A和petasin都是在偏头痛预防和治疗方面显示出很大前景的新药。有必要进行更多的研究，以更好地了解其抗偏头痛作用，确认其有效性和安全性，并将其引入临床实践。

关键词: 头痛，治疗偏头痛的天然化合物，伤害感受，新靶点，疼痛，治疗

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