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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Editorial

Crosstalk Between Nutrients and Xenobiotic Receptors

Author(s): Xi Ma

Volume 20, Issue 1, 2019

Page: [3 - 3] Pages: 1

DOI: 10.2174/138920022001190125110856

[1]
Ma, X.; Chen, J.; Tian, Y. Pregnane X receptor as the “sensor and effector” in regulating epigenome. J. Cell. Physiol., 2015, 230, 752-757.
[2]
King-Jones, K.; Horner, M.A.; Lam, G.; Thummel, C.S. The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. Cell Metab., 2006, 4, 37-48.
[3]
Hahn, M.E. Aryl hydrocarbon receptors: Diversity and evolution. Chem. Biol. Interact., 2002, 141, 131-160.
[4]
Pascussi, J.M.; Gerbal-Chaloin, S.; Duret, C.; Daujat-Chavanieu, M.; Vilarem, M.J.; Maurel, P. The tangle of nuclear receptors that controls xenobiotic metabolism and transport: Crosstalk and consequences. Annu. Rev. Pharmacol. Toxicol., 2008, 48, 1-32.
[5]
Venkatesh, M.; Mukherjee, S.; Wang, H.; Li, H.; Sun, K.; Benechet, A.P.; Qiu, Z.; Maher, L.; Redinbo, M.R.; Phillips, R.S.; Fleet, J.C.; Kortagere, S.; Mukherjee, P.; Fasano, A.; Le Ven, J.; Nicholson, J.K.; Dumas, M.E.; Khanna, K.M.; Mani, S. Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4. Immunity, 2014, 41, 296-310.
[6]
Krausgruber, T.; Blazek, K.; Smallie, T.; Alzabin, S.; Lockstone, H.; Sahgal, N.; Hussell, T.; Feldmann, M.; Udalova, I.A. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat. Immunol., 2011, 12, 231-238.
[7]
Biswas, S.K.; Lopez-Collazo, E. Endotoxin tolerance: New mechanisms, molecules and clinical significance. Trends Immunol., 2009, 30, 475-487.
[8]
Schiering, C.; Wincent, E.; Metidji, A.; Iseppon, A.; Li, Y.; Potocnik, A.J.; Omenetti, S.; Henderson, C.J.; Wolf, C.R.; Nebert, D.W.; Stockinger, B. Feedback control of AHR signalling regulates intestinal immunity. Nature, 2017, 542, 242-245.
[9]
Zelante, T.; Iannitti, R.G.; Cunha, C.; De Luca, A.; Giovannini, G.; Pieraccini, G.; Zecchi, R.; D’Angelo, C.; Massi-Benedetti, C.; Fallarino, F.; Carvalho, A.; Puccetti, P.; Romani, L. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity, 2013, 39, 372-385.
[10]
Zelante, T.; Iannitti, R.G.; Fallarino, F.; Gargaro, M.; De Luca, A.; Moretti, S.; Bartoli, A.; Romani, L. Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis. Front. Immunol., 2014, 5, 640.
[11]
Lanis, J.M.; Alexeev, E.E.; Curtis, V.F.; Kitzenberg, D.A.; Kao, D.J.; Battista, K.D.; Gerich, M.E.; Glover, L.E.; Kominsky, D.J.; Colgan, S.P. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. Mucosal Immunol., 2017 . In press

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