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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Selective α,α-Dibromination of Arylethanones with Copper(II) Bromide

Author(s): Jitander K. Kapoor, Loveena Arora* and Om Prakash

Volume 16, Issue 9, 2019

Page: [700 - 704] Pages: 5

DOI: 10.2174/1570178616666190118152325

Price: $65

Abstract

Various arylethanones including electron-rich aromatic ketones such as o-hydroxyacetophenone and its p-isomer underwent selective side-chain α,α-dibromination using a heterogeneous system consisting of four molar equivalents of copper(II) bromide in chloroform-ethyl acetate under reflux. This study provides the cleanest method for the selective synthesis of several synthetically useful α,α-dibromoketones which are otherwise difficult to prepare.

Keywords: o/p-Hydroxyacetophenone, heterogeneous system, side-chain dibromination, arylethanones, copper(II) bromide, bromoketone.

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