Abstract
Cancer arises as the result of sequential alterations in growth-controlling genes. Epigenetic factors, such as angiogenesis and surrounding micro-environment can also affect cancer initiation and progression. Tumorigenesis is accompanied by important changes in gene expression in the tumor cell as compared to its normal counterpart. The advent of powerful new techniques such as microarray technology and SAGE has allowed the study of gene expression in neoplastic cells at a scale never before accomplished. Indeed, it is now possible to efficiently measure the levels of thousands of genes expressed in normal and tumor tissues. This global knowledge of gene expression allows the identification of differentially expressed genes and, in principle, the understanding of the complex molecular circuitry regulating normal and neoplastic growth. Such studies have led to molecular profiling of tumors, which have suggested general methods for distinguishing tumors of various biological behaviors (molecular classi fication), elucidating pathways relevant to the tumorigenesis process, and identifying targets for the detection (biomarkers) and mechanism-based therapy of cancer. The next challenge will be the implementation of these breakthroughs in the clinic, as well as the extension of these paradigms to the fields of proteomics and physiomics.
Current Genomics
Title: Functional Genomics Approaches in Cancer Research
Volume: 3 Issue: 5
Author(s): Patrice J. Morin
Affiliation:
Abstract: Cancer arises as the result of sequential alterations in growth-controlling genes. Epigenetic factors, such as angiogenesis and surrounding micro-environment can also affect cancer initiation and progression. Tumorigenesis is accompanied by important changes in gene expression in the tumor cell as compared to its normal counterpart. The advent of powerful new techniques such as microarray technology and SAGE has allowed the study of gene expression in neoplastic cells at a scale never before accomplished. Indeed, it is now possible to efficiently measure the levels of thousands of genes expressed in normal and tumor tissues. This global knowledge of gene expression allows the identification of differentially expressed genes and, in principle, the understanding of the complex molecular circuitry regulating normal and neoplastic growth. Such studies have led to molecular profiling of tumors, which have suggested general methods for distinguishing tumors of various biological behaviors (molecular classi fication), elucidating pathways relevant to the tumorigenesis process, and identifying targets for the detection (biomarkers) and mechanism-based therapy of cancer. The next challenge will be the implementation of these breakthroughs in the clinic, as well as the extension of these paradigms to the fields of proteomics and physiomics.
Export Options
About this article
Cite this article as:
Morin J. Patrice, Functional Genomics Approaches in Cancer Research, Current Genomics 2002; 3 (5) . https://dx.doi.org/10.2174/1389202023350309
DOI https://dx.doi.org/10.2174/1389202023350309 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Nuclear Steroid Receptors in Apoptosis
Current Medicinal Chemistry Phenolic Compounds as Nutraceuticals or Functional Food Ingredients
Current Pharmaceutical Design Applications of Nanosystems to Anticancer Drug Therapy (Part I. Nanogels, Nanospheres, Nanocapsules)
Recent Patents on Anti-Cancer Drug Discovery G-Quadruplex Interacting Agents Targeting the Telomeric G-Overhang Are More than Simple Telomerase Inhibitors
Current Medicinal Chemistry - Anti-Cancer Agents Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review
Current Genomics Understanding Autophagy in Cell Death Control
Current Pharmaceutical Design Recombinant Immunotoxins for the Treatment of Chemoresistant Hematologic Malignancies
Current Pharmaceutical Design Review on Documented Medicinal Plants used for the Treatment of Cancer
Current Traditional Medicine Potentials and Challenges of Active Targeting at the Tumor Cells by Engineered Polymeric Nanoparticles
Current Pharmaceutical Biotechnology New Functions of the Inositol Polyphosphate 5-Phosphatases in Cancer
Current Pharmaceutical Design The Hippocampal Autophagic Machinery is Depressed in the Absence of the Circadian Clock Protein PER1 that may Lead to Vulnerability During Cerebral Ischemia
Current Neurovascular Research Nasal Polyposis: An Overview of Differential Diagnosis and Treatment
Recent Patents on Inflammation & Allergy Drug Discovery Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer
Recent Patents on Anti-Cancer Drug Discovery Research Strategies for Pain in Lumbar Radiculopathy Focusing on Acid-Sensing Ion Channels and Their Toxins
Current Topics in Medicinal Chemistry The Effects of Colchicum baytopiorum on Regulatory Genes of Apoptotic and Autophagic Cell Death in HeLa Cells
Current Pharmaceutical Biotechnology Drug Design Targeting the CXCR4/CXCR7/CXCL12 Pathway
Current Topics in Medicinal Chemistry Molecular Imaging of Therapeutic Potential of Reporter Probes
Current Drug Targets Oncolytic Viruses Driven by Tumor-Specific Promoters
Current Cancer Drug Targets DTCM-glutarimide Delays Growth and Radiosensitizes Glioblastoma
Anti-Cancer Agents in Medicinal Chemistry Cellular Functions of Vaults and their Involvement in Multidrug Resistance
Current Drug Targets