Abstract
Secreted aspartic proteinases (Saps) are important virulence factors in different types of candidiasis caused by Candida albicans (C. albicans). The various isoenzymes are expected to fulfil different tasks during mucosal or disseminated infections. It could be shown that the introduction of the proteinase inhibitors like saquinavir and indinavir in the therapy of human immunodeficiency virus (HIV) infected patients has an effect on Sap activity in vitro as well as in vivo. Therefore, drugs like the HIV proteinase inhibitors could play an essential role in the treatment of candidiasis in the future, especially if further adapted to this target.
Current Drug Targets
Title: The Secreted Aspartic Proteinases as a New Target in the Therapy of Candidiasis
Volume: 3 Issue: 5
Author(s): M. Bein, M. Schaller and H.C. Korting
Affiliation:
Abstract: Secreted aspartic proteinases (Saps) are important virulence factors in different types of candidiasis caused by Candida albicans (C. albicans). The various isoenzymes are expected to fulfil different tasks during mucosal or disseminated infections. It could be shown that the introduction of the proteinase inhibitors like saquinavir and indinavir in the therapy of human immunodeficiency virus (HIV) infected patients has an effect on Sap activity in vitro as well as in vivo. Therefore, drugs like the HIV proteinase inhibitors could play an essential role in the treatment of candidiasis in the future, especially if further adapted to this target.
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Cite this article as:
M. Bein , M. Schaller and H.C. Korting , The Secreted Aspartic Proteinases as a New Target in the Therapy of Candidiasis, Current Drug Targets 2002; 3 (5) . https://dx.doi.org/10.2174/1389450023347542
DOI https://dx.doi.org/10.2174/1389450023347542 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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