Synthetic Approaches to Organoselenium Derivatives with Antimicrobial and Anti-Biofilm Activity

Iris       Di Leo; Federica       Messina; Vanessa       Nascimento; Francesca    G.   Nacca; Donatella       Pietrella; Eder    J.    Lenardão; Gelson       Perin; Luca      Sancineto
doi:10.2174/1570193X16666181227111038
Abstract

In the recent years, an increasing attention has been given to the biological activities exerted by organoselenium compounds. In 1984, Sies reported for the first time the ability of ebselen to mimic the activity of glutathione peroxidase. From this milestone, several studies reported the pharmacological properties of selenium-containing compounds including their exploitation as antimicrobials. In this context, this minireview presents the most recent examples of seleno derivatives endowed with antimicrobial activities while discussing the most interesting and recent synthetic procedures used to obtain these compounds.
Keywords: Biofilm, diselenides, gram-negative bacteria, gram-positive bacteria, selenium, benzoisoselenazolones.
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DOI https://dx.doi.org/10.2174/1570193X16666181227111038	Print ISSN 1570-193X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6298
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Synthetic Approaches to Organoselenium Derivatives with Antimicrobial and Anti-Biofilm Activity

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