Abstract
In this review we introduced many kinds of bifunctional N-substituted amides, including phosphinamides and phosphoramides, squaramides, sulfonamides and so on which were applied to the asymmetric reactions. More emphasis were given to the asymmetric borane reduction of prochiral ketones, the reaction conditions and mechanisms were discussed systematically. At the same time, other reactions, including asymmetric addition, Diels-Alder reaction and Aldol reactions catalyzed by chiral N-substituted amides were also reviewed.
Keywords: N-Substituted Amides, Chiral Ligands, squaramides
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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