摘要
维生素A及其衍生物（类视黄醇）在哺乳动物生殖，发育，修复和维持分化组织功能的许多方面充当有效的调节剂。与其他维生素不同，具有激素作用的维生素A和类维生素A具有显着的毒性，其在临床相关情况中起作用，例如维生素A过多症和视黄酸（“分化”）综合征。尽管在维生素A和维甲酸浓度不足或过量的状态下临床表现显着，但对宿主对特定感染因子的抵抗以及免疫稳态的一般维持的同等相关影响可能会被忽视，因为它们的表达需要病原体暴露或存在炎症性合并症。关于类维生素A在肠道粘膜中维持致耐受性，非炎性环境所起作用的文献很多，许多研究者认为这种文献代表了类维生素A作为其他地方的抗炎激素所起的一般作用。然而，在肠粘膜本身以及骨髓和炎症部位中，上下文确定是否观察到类维生素A的抗炎或促炎作用。特定细胞群之间的相互作用以及类维生素A和其他类型的介质/调节剂（例如细胞因子和糖皮质激素）之间的相互作用必须被视为促成这种总体背景的重要因素。我们回顾了最近关于粘膜免疫，粒细胞生物学和呼吸道过敏模型的研究的证据，强调了这些变量的相关性以及它们对观察结果的可能贡献。
关键词: 类视黄醇，免疫调节，调节性T细胞，树突状T细胞，粒细胞，糖皮质激素。
图形摘要
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