Generic placeholder image

Current Organocatalysis

Editor-in-Chief

ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

Research Article

Fe3O4@L-arginine as a Reusable Catalyst for the Synthesis of Polysubstituted 2-Pyrrolidinones

Author(s): Mohammad Ali Ghasemzadeh*, Mohammad Hossein Abdollahi-Basir and Zahra Elyasi

Volume 6, Issue 1, 2019

Page: [61 - 68] Pages: 8

DOI: 10.2174/2213337206666181211125226

Abstract

Background: This research introduces an effective and green method for the synthesis of polysubstituted 2-pyrrolidinone derivatives as biologically-active heterocyclic compounds using multi- component reactions using Fe3O4@L-arginine as a reusable organocatalyst.

Material and Method: The Fe3O4@L-arginine nanoparticles were prepared by a facile one-step approach and the structure elucidation of the magnetic nanocatalyst has been done using various spectroscopy techniques.

Results: L-arginine-functionalized magnetite nanoparticles were obtained with particle sizes around 10 nm. Fe3O4@L-arginine exhibited strong catalytic activity to obtain some polysubstituted 2- pyrrolidinone.

Conclusion: The considerable advantages of this research are short reaction times, excellent yields, simple workup procedure and reusability of the nanocatalyst which is in good agreement with green chemistry disciplines. The study on the reusability of the Fe3O4@L-arginine nanoparticles showed that the recovered catalyst could be reused six consecutive times.

Keywords: Fe3O4@L-arginine, multi-component reaction, nanocatalyst, pyrrolidinone, solvent-free, catalytic.

Graphical Abstract

[1]
Do¨mling, A.; Ugi, I. Multicomponent Reactions with Isocyanides. Angew. Chem. Int. Ed., 2000, 39, 3168-3210.
[2]
Ghasemzadeh, M.A.; Safaei-Ghomi, J.; Zahedi, S. Fe3O4 nanoparticles: A highly efficient and easily reusable catalyst for the one-pot synthesis of xanthene derivatives under solvent-free conditions. J. Serb. Chem. Soc., 2013, 78, 769-779.
[3]
De Meijere, A.; Nu¨ske, H.; Es-Sayed, M.; Labahn, T.; Schroen, M.; Bra¨se, S. New efficient multicomponent reactions with c-c coupling for combinatorial application in liquid and on solid phase. Angew. Chem. Int. Ed., 1999, 38, 3669-3672.
[4]
Ghasemzadeh, M.A.; Elyasi, Z.; Azimi-Nasrabad, M.; Mirhosseini Eshkevari, B. Magnetite nanoparticles-supported APTES as a powerful and recoverable nanocatalyst for the preparation of 2-amino-5,10-dihydro- 5,10-dioxo-4H-benzo[g]chromenes and tetrahydrobenzo[g]quinoline-5,10- diones. Comb. Chem. High Throughput Screen., 2017, 20, 64-76.
[5]
Atacan, K.; Çakırog˘lu, B.; Özacar, M. Improvement of the stability and activity of immobilized trypsin on modified Fe3O4 magnetic nanoparticles for hydrolysis of bovine serum albumin and its application in the bovine milk. Food Chem., 2016, 212, 460-468.
[6]
Umegaki, T.; Xu, Q.; Kojima, Y. Effect of l-arginine on the catalytic activity and stability of nickel nanoparticles for hydrolytic dehydrogenation of ammonia borane. J. Power Sources, 2012, 216, 363-367.
[7]
Rajabi, H.R.; Arjmand, H.; Hoseini, S.J.; Nasrabadi, H. Surface modified magnetic nanoparticles as efficient and green sorbents: Synthesis, characterization, and application for the removal of anionic dye. J. Magn. Magn. Mater., 2015, 394, 7-13.
[8]
Zhang, Y.R.; Su, P.; Huang, J.; Wang, Q.R.; Zhao, B.X. A magnetic nanomaterial modified with poly-lysine for efficient removal of anionic dyes from water. Chem. Eng. J., 2015, 262, 313-318.
[9]
Shariati, S.; Faraji, M.; Yamini, Y.; Rajabi, A.A. Fe3O4 magnetic nanoparticles modified with sodium dodecyl sulfate for removal of safranin O dye from aqueous solutions. Desalination, 2011, 270, 160-165.
[10]
Zhang, C.; Shan, C.; Jin, Y.; Tong, M. Enhanced removal of trace arsenate by magnetic nanoparticles modified with arginine and lysine. Chem. Eng. J., 2014, 254, 340-348.
[11]
Jin, Y.; Liu, F.; Shan, C.; Tong, M.; Hou, Y. Efficient bacterial capture with amino acid modified magnetic nanoparticles. Water Res., 2014, 50, 124-134.
[12]
Gao, H.; Sun, J.; Yan, C.G. Synthesis of functionalized 2-pyrrolidinones via domino reactions of arylamines, ethyl glyoxylate and acetylenedicarboxylates. Tetrahedron, 2013, 69, 589-594.
[13]
(a) Adam, W.; Zhang, A. High π‐facial selectivity through chelation of magnesium ions in the DMD epoxidation of α,β‐unsaturated imides with chiral pyrrolidinone auxiliaries. Eur. J. Org. Chem., 2004, 1, 147-152.
(b) Moutevelis-Minakakis, P.; Gianni, M.; Stougiannou, H.; Zoumpoulakis, P.; Zoga, A.; Vlahakos, A.D. iliodromitis, E.; Mavromoustakos, T. Design and synthesis of novel antihypertensive drugs. Bioorg. Med. Chem. Lett., 2003, 13, 1737-1340.
(c) Mavromoustakos, T.; Moutevelis Minakakis, P.; Kokotos, C.G.; Kontogianni, P.; Politi, A.; Zoumpoulakis, P.; Findlay, J.; Cox, A.; Balmforth, A.; Zoga, A.; Iliodromitis, E. Synthesis, binding studies and in vivo biological evaluation of novel non-peptide antihypertensive analogues. Bioorg. Med. Chem., 2006, 14, 4353-4360.
[14]
Ma, K.; Wang, P.; Fu, W.; Wan, X.; Zhou, L.; Chu, Y.; Ye, D. Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase. Bioorg. Med. Chem. Lett., 2011, 21, 6724-6727.
[15]
Thamotharan, S.; Parthasarathi, V.; Malik, R.; Jindal, D.P.; Piplani, P. 2-[(2-Oxopyrrolidin-1-yl)carbonylmethyl]- 2,3-dihydro-1 H -isoindole-1,3-dione: an antiamnesic agent. Act. Crys., 2003, E59, 1012-1013.
[16]
Becker, M.R.; Ewing, W.R.; Davis, R.S.; Pauls, H.W.; Li, C.; Li, A.; Mason, H.J.; Choi-Sledeski, Y.M.; Spada, A.P.; Chu, V. Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors. Bioorg. Med. Chem. Lett., 1999, 9, 2753-2758.
[17]
Brychtova, K.; Jampilek, J.; Opatrilova, R.; Raich, I.; Farsa, O. sollei, J. C. Synthesis, physico-chemical properties and penetration activity of alkyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoates as potential transdermal penetration enhancers. Bioorg. Med. Chem., 2010, 18, 73-79.
[18]
Reddy, P.A.; Hsiang, B.C.; Latifi, T.N.; Hill, M.W.; Woodward, K.E.; Rothman, S.M.; Ferrendelli, J.A.; Covey, D.F. 3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents. J. Med. Chem., 1996, 26, 1898-1906.
[19]
Patel, N.; Singh, A.; Gupta, D.K. Synthesis, spectral and antimicrobial studies of new 2-pyrrolidinones containing benzofuran moiety. Rasayan J. Chem., 2015, 8, 207-212.
[20]
Gao, H.; Sun, J.; Yan, C.G. Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate. Beilstein J. Org. Chem., 2013, 9, 2934-2939.
[21]
Goksu, H.; Zengin, N.; Arife Karaosman, A.; Sen, F. Highly active and reusable Pd/AlO(OH) nanoparticles for the suzuki cross-coupling reaction. Curr. Organocatal., 2018, 5, 34-41.
[22]
Pamuka, H.; Adayb, B.; Şena, F.; Kayaa, M. Pt NPs@GO as Highly efficient and reusable catalyst for one-pot synthesis of acridinedione derivatives. RSC Advances, 2015, 5, 49295-49300.
[23]
Goksu, H.; Yıldız, Y.; Çelik, B.; Yazici, M.; Kilbas, B.; Sen, F. Eco-friendly hydrogenation of aromatic aldehyde compounds by tandem dehydrogenation of dimethylamine-borane in the presence of a reduced graphene oxide furnished platinum nanocatalyst. Catal. Sci. Technol., 2016, 6, 2318-2324.
[24]
Esirden, I.; Esma Erken, E.; Kaya, M.; Sen, S. Monodisperse Pt NPs@rGO as highly efficient and reusable heterogeneous catalysts for the synthesis of 5-substituted 1H-tetrazole derivatives. Catal. Sci. Technol., 2015, 5, 4452-4457.
[25]
Aday, B.; Yıldız, Y.; Ulus, R.; Sinan Eris, S.; Fatih Sen, F.; Kaya, M. One-pot, efficient and green synthesis of acridinedione derivatives using highly monodisperse platinum nanoparticles supported with reduced graphene oxide. New J. Chem., 2016, 40, 748-754.
[26]
Erken, E.; Esirden, I.; Kaya, M.; Sen, F. A rapid and novel method for the synthesis of 5-substituted 1H-tetrazole catalyzed by exceptional reusable monodisperse Pt NPs@AC under the microwave irradiation. RSC Advances, 2015, 5, 68558-68564.
[27]
Aday, B.; Pamuk, H.; Kaya, M.; Sen, F. Graphene oxide as highly effective and readily recyclable catalyst using for the one-pot synthesis of 1, 8-dioxoacridine derivatives. J. Nanosci. Nanotechnol., 2016, 16, 6498-6504.
[28]
Göksu, H.; Yunus Yıldız, Y.; Celik, B.; Yazıcı, M.; Kilbas, B.; Sen, F. Highly efficient and monodisperse graphene oxide furnished Ru/Pd nanoparticles for the dehalogenation of aryl halides via ammonia borane. ChemistrySelect, 2016, 5, 953-958.
[29]
Akocak, S.; Şen, B.; Lolak, N.; Şavk, A.; Koca, M.; Kuzu, S.; Şen, F. One-pot three-component synthesis of 2-Amino-4H-Chromene derivatives by using monodisperse Pd nanomaterials anchored graphene oxide as highly efficient and recyclable catalyst. Nano-Structures & Nano-Objects, 2017, 11, 25-31.
[30]
Goksu, H.; Celik, B.; Yıldız, Y.; Sen, F.; Kılbas, B. Superior monodisperse CNT-supported CoPd (CoPd@CNT) nanoparticles for selective reduction of nitro compounds to primary amines with NaBH4 in aqueous medium. ChemistrySelect, 2016, 1, 2366-2372.
[31]
Demirci, T.; Çelik, B.; Yıldız, Y.; Eriş, S.; Arslan, M.; Sen, F.; Kilbas, B. One-pot synthesis of Hantzsch dihydropyridines using a highly efficient and stable PdRuNi@GO catalyst. RSC Advances, 2016, 6, 76948-76956.
[32]
Gaye Baskaya, G.; Esirden, E.; Erken, E.; Sen, F.; Kaya, M. Synthesis of 5-substituted-1H-tetrazole derivatives using monodisperse carbon black decorated pt nanoparticles as heterogeneous nanocatalysts. J. Nanosci. Nanotechnol., 2017, 17, 1992-1999.
[33]
Zamani, F.; Hosseini, S.M. Palladium nanoparticles supported on Fe3O4/amino acid nanocomposite: Highly active magnetic catalyst for solvent-free aerobic oxidation of alcohols. Catal. Commun., 2014, 43, 164-168.
[34]
Nakamoto, K. Infrared and raman spectra of inorganic and coordination compounds; Wiley: New York, 1986.
[35]
Yu, S.; Chow, G.M. Carboxyl group (–CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications. J. Mater. Chem., 2004, 14, 2781-2786.
[36]
Ma, M.; Zhang, Y.; Yu, W.; Shen, H.Y.; Zhang, H.Q.; Gu, N. Preparation and characterization of magnetite nanoparticles coated by amino silane. Colloids Surf. A , 2003, 212, 219-226.
[37]
Qu, H.; Ma, H.; Zhou, W.; O’Connor, C.J. In situ surface functionalization of magnetic nanoparticles with hydrophilic natural amino acids. Inorg. Chim. Acta, 2012, 389, 60-65.
[38]
Sarkar, R.; Mukhopadhyay, C.H. Admicellar catalysis in multicomponent synthesis of polysubstituted pyrrolidinones. Tetrahedron Lett., 2013, 54, 3706-3711.
[39]
Gao, H.; Sun, J.; Yan, C.G. Synthesis of functionalized 2-pyrrolidinones via domino reactions of arylamines, ethyl glyoxilate and acetylenedicarboxylates. Tetrahedron, 2013, 69, 589-594.
[40]
Wdowik, T.; Chemler, S.H. Direct Synthesis of 2-formylpyrrolidines, 2-pyrrolidinones and 2-dihydrofuranones via aerobic copper-catalyzed aminooxygenation and dioxygenation of 4-pentenylsulfonamides and 4-pentenylalcohols. J. Am. Chem. Soc., 2017, 139, 9515-9518.
[41]
Joseph, Y.; Kuhrs, C.; Ranke, W.; Ritter, M.; Weiss, W. Adsorption of water on FeO(111) and Fe3O4 (111): identification of active sites for dissociation. Chem. Phys. Lett., 1999, 314, 195-202.
[42]
Hartlen, K.D.; Athanasopoulos, A.P.T.; Kitaev, V. Facile preparation of highly monodisperse small silica spheres (15 to >200 nm) suitable for colloidal templating and formation of ordered Arrays. Langmuir, 2008, 24, 1714-1720.
[43]
Azizi, Kobra. Karimi, Meghdad.; Shaterian, H.R. Heydari, A. Ultrasound irradiation for the green synthesis of chromenes using L-arginine-functionalized magnetic nanoparticles as a recyclable organocatalyst. RSC Advances, 2015, 4, 42220-42225.

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version2.48sRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[15:30:37] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[15:30:38] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[15:30:38] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (552ms)time
  • Application (1.93s)time
  • 1 x Application (77.76%)
    1.93s
    1 x Booting (22.24%)
    552ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    31 statements were executed, 4 of which were duplicates, 27 unique. Show only duplicated1.82s
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('873346344','',1,1740497437,1740497437) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1740497437
      255msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('873346344','/article/95161',1,1740497437,1740497437)
      2.13msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 873346344 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 873346344) limit 1
      859msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 873346344
      • 1: 873346344
      • 2: 873346344
      • 3: 873346344
      • 4: 873346344
      • 5: 873346344
      • 6: 873346344
      • 7: 873346344
      • 8: 873346344
      • 9: 873346344
      • 10: 873346344
      • 11: 873346344
      • 12: 873346344
      • 13: 873346344
      • 14: 873346344
      • 15: 873346344
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=95161
      1.21msalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 143 limit 1
      235msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 143
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=143) and sj.journal_id!=143 group by `j`.`nid`) as `aggregate_table`
      211msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=143) and sj.journal_id!=143 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      860μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=143) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      86.49msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=143) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      53.45msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '95161'
      31.01msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 95161
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '95161'
      12.15msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 95161
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '95161' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3.88msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 95161
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      360μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      760μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 143 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      45.57msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 143 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      4.1msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 143 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      2.8msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 95161 limit 1
      310μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 95161
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 95161 and content_type = 'article' order by status desc limit 1
      360μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 168262 limit 1
      300μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 168262
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      350μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'COCAT' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      400μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: COCAT
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '95161' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      520μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '61' and is_uploaded = 1 and issue_id = 9011 order by cast(first_page as SIGNED) desc limit 1
      660μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 61
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '68' and is_uploaded = 1 and issue_id = 9011 order by cast(first_page as SIGNED) asc limit 1
      750μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 68
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      240μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      310μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 95161 limit 1
      3.98msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 95161
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 143 and `b`.`banner_from_date` <= 1740497438 and `b`.`banner_to_date` >= 1740497438 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.61msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 143
      • 3: 1740497438
      • 4: 1740497438
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 143 and `b`.`banner_from_date` <= 1740497438 and `b`.`banner_to_date` >= 1740497438 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.61msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 143
      • 3: 1740497438
      • 4: 1740497438
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='567a556e825925e1a3258dcdaf8e2e8a'
      310μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        hE7LgBfYmR388KOAKG5kE6rMgR6yJNcNs7GkZttX
        uc_cart_id
        567a556e825925e1a3258dcdaf8e2e8a
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/95161" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/95161
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6ImNWNlVyOGt5OER3Ty95alkvVHdRTXc9PSIsInZhbHVlIjoiWkkyeUp4QnJHWnkwb0FOZGx0NEhHbXJQOXc5d0l4Tjl6b1pubEt6YkRUWT0iLCJtYWMiOiJiZjc0YmMxOGE4ZmFkZDBlMGRiMTJlYmVlMDEyMTI4Y2NhYzdjNWVhODQ3YjVlOWZiNzJlNTQ5OGExOTA3NmJjIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6ImNWNlVyOGt5OER3Ty95alkvVHdRTXc9PSIsInZhbHVlIjoiWkkyeUp4QnJHWnkwb0FOZGx0NEhHbXJQOXc5d0l4Tjl6b1pubEt6YkRUWT0iLCJtYWMiOiJiZjc0YmMxOGE4ZmFk" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Tue, 25 Feb 2025 15:30:38 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InV0SkZXZzlhSnI5bW53cUxBdnc5ZXc9PSIsInZhbHVlIjoiYXFzaEtCMTM2ZUEvbkw1c0p3cjVXaENtSEhlZVFRclp1NFlZdEZETGVTK0xQYlh2aG56ZVQ0OFpNZGc2MnV4OGxTZW5HZXdjSitaR1VhR25hUnhLTUF1UzNqa1A1L2VpSXQ3SDI0OVVEVThiWldqZGN0VklLbHloYm1VdWxCeHMiLCJtYWMiOiJhNjY3ZjgyYjQ4NDYzN2QzNTNmMjk5YWJkMTQxZmViMWQyOTkzMGIyMjU0ODM3MWRlZDYxNDU0NDA4ZWRmYmQ4IiwidGFnIjoiIn0%3D; expires=Fri, 28 Feb 2025 03:30:39 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6InV0SkZXZzlhSnI5bW53cUxBdnc5ZXc9PSIsInZhbHVlIjoiYXFzaEtCMTM2ZUEvbkw1c0p3cjVXaENtSEhlZVFRclp1NFlZdEZETGVTK0xQYlh2aG56ZVQ0OFpNZGc2MnV4OGxTZW5HZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ii8zbXlvdG1rcTRmNUxRa24zZC8yNVE9PSIsInZhbHVlIjoiSTdod3lNTDVqQmdsVUYrL3lEbW5hS0lxUk56V2Z4QXc2Tkk4TjFYUVh6Rno5RXNDS0dGdzlNNFFsSzVVbkNWS09jTjl0T1V3eFMvK0tCc3o3d1ppTWFQTk00aFkxRmdSYkR0NkZxUDZmbnhuWjZpdGhBZ0FiTkplUmJON3QrTzUiLCJtYWMiOiI1NjA3MmVhZWYxZjVlZTkwZGJhNjM2Yzg3YTEyMjQxNDA3ZmRlZWFhM2UzYzk1YWE4ZmZkOWFkNTY0ODY4NzEyIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Ii8zbXlvdG1rcTRmNUxRa24zZC8yNVE9PSIsInZhbHVlIjoiSTdod3lNTDVqQmdsVUYrL3lEbW5hS0lxUk56V2Z4QXc2Tkk4TjFYUVh6Rno5RXNDS0dGdzlNNFF" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6InV0SkZXZzlhSnI5bW53cUxBdnc5ZXc9PSIsInZhbHVlIjoiYXFzaEtCMTM2ZUEvbkw1c0p3cjVXaENtSEhlZVFRclp1NFlZdEZETGVTK0xQYlh2aG56ZVQ0OFpNZGc2MnV4OGxTZW5HZXdjSitaR1VhR25hUnhLTUF1UzNqa1A1L2VpSXQ3SDI0OVVEVThiWldqZGN0VklLbHloYm1VdWxCeHMiLCJtYWMiOiJhNjY3ZjgyYjQ4NDYzN2QzNTNmMjk5YWJkMTQxZmViMWQyOTkzMGIyMjU0ODM3MWRlZDYxNDU0NDA4ZWRmYmQ4IiwidGFnIjoiIn0%3D; expires=Fri, 28-Feb-2025 03:30:39 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6InV0SkZXZzlhSnI5bW53cUxBdnc5ZXc9PSIsInZhbHVlIjoiYXFzaEtCMTM2ZUEvbkw1c0p3cjVXaENtSEhlZVFRclp1NFlZdEZETGVTK0xQYlh2aG56ZVQ0OFpNZGc2MnV4OGxTZW5HZ" 1 => "alphaeurekaselectnet_session=eyJpdiI6Ii8zbXlvdG1rcTRmNUxRa24zZC8yNVE9PSIsInZhbHVlIjoiSTdod3lNTDVqQmdsVUYrL3lEbW5hS0lxUk56V2Z4QXc2Tkk4TjFYUVh6Rno5RXNDS0dGdzlNNFFsSzVVbkNWS09jTjl0T1V3eFMvK0tCc3o3d1ppTWFQTk00aFkxRmdSYkR0NkZxUDZmbnhuWjZpdGhBZ0FiTkplUmJON3QrTzUiLCJtYWMiOiI1NjA3MmVhZWYxZjVlZTkwZGJhNjM2Yzg3YTEyMjQxNDA3ZmRlZWFhM2UzYzk1YWE4ZmZkOWFkNTY0ODY4NzEyIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Ii8zbXlvdG1rcTRmNUxRa24zZC8yNVE9PSIsInZhbHVlIjoiSTdod3lNTDVqQmdsVUYrL3lEbW5hS0lxUk56V2Z4QXc2Tkk4TjFYUVh6Rno5RXNDS0dGdzlNNFF" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "hE7LgBfYmR388KOAKG5kE6rMgR6yJNcNs7GkZttX" "uc_cart_id" => "567a556e825925e1a3258dcdaf8e2e8a" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/95161" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-25 15:30:39GET/article/95161314311