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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

介孔二氧化硅纳米粒子作为药物传递和生物医学应用的前瞻性和有前途的方法

卷 19, 期 4, 2019

页: [285 - 295] 页: 11

弟呕挨: 10.2174/1568009619666181206114904

价格: $65

摘要

背景：纳米载体随着纳米技术的发展，近年来已广泛应用于药物输送，诊断，医学成像和工程等领域。在所有可用的纳米载体中，介孔二氧化硅纳米粒子（MSNs）由于其独特的性质，例如大的表面积和空隙率，可调的药物负载能力和释放动力学，良好的生物安全性和易于改性的表面而成为热门问题。 目的：我们根据不同类型的货物描述了二氧化硅辅助药物输送和生物医学应用的最新进展，以便研究人员能够快速了解该领域的进展。 方法：从最近发表的文献中收集信息，主要通过SpringerLink和PubMed数据库中的标题或抽象搜索获得。特别强调2008 - 2017年期间的文献。 结果：本文综述了MSNs在药物输送和生物医学应用方面的主要研究进展。 MSN的显着优点也已列出。发现需要解决和研究几个重大挑战，以进一步推进这些结构上定义的纳米材料的应用。 结论：通过接近这篇综述，研究人员可以了解许多新的合成方法，近年提出的智能设计以及目前仍存在的MSN问题。

关键词: 介孔二氧化硅纳米粒子，制造技术，药物输送，生物医学应用，抗癌和靶标，临床前试验。

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