Discovery of Dengue Virus Inhibitors

Adib    Afandi    Abdullah; Yean    Kee    Lee; Sek    Peng    Chin; See    Khai    Lim; Vannajan    Sanghiran    Lee; Rozana       Othman; Shatrah       Othman; Noorsaadah    Abdul    Rahman; Rohana       Yusof; Choon    Han    Heh
doi:10.2174/0929867326666181204155336
Abstract

To date, there is still no approved anti-dengue agent to treat dengue infection in the market. Although the only licensed dengue vaccine, Dengvaxia is available, its protective efficacy against serotypes 1 and 2 of dengue virus was reported to be lower than serotypes 3 and 4. Moreover, according to WHO, the risk of being hospitalized and having severe dengue increased in seronegative individuals after they received Dengvaxia vaccination. Nevertheless, various studies had been carried out in search of dengue virus inhibitors. These studies focused on the structural (C, prM, E) and non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) of dengue virus as well as host factors as drug targets. Hence, this article provides an overall up-to-date review of the discovery of dengue virus inhibitors that are only targeting the structural and non-structural viral proteins as drug targets.
Keywords: Drug discovery, dengue virus, virus inhibitors, structural proteins, non-structural proteins, drug targets.
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DOI https://dx.doi.org/10.2174/0929867326666181204155336	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

Discovery of Dengue Virus Inhibitors

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