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Systematic Review Article

促炎细胞因子在骨骼肌代谢调控中的作用：系统评价

卷 27, 期 13, 2020

页: [2161 - 2188] 页: 28

弟呕挨: 10.2174/0929867326666181129095309

价格: $65

摘要

背景：由于分解代谢增加，代谢途径的扰动导致恶病质和少肌症的骨骼肌萎缩。促炎性细胞因子诱导破坏肌肉完整性和功能的分解代谢途径。因此，本综述主要集中于促炎细胞因子在调节骨骼肌代谢中的作用。 目的：本综述将探讨促炎细胞因子在肌肉消瘦过程中在骨骼肌中的作用。此外，将讨论促炎细胞因子之间的协调及其增加蛋白质降解的调控分子信号通路。 结果：在正常情况下，需要促炎细胞因子来平衡合成代谢和分解代谢并维持正常的肌生成过程。然而，在肌肉消瘦期间，它们的增强表达导致骨骼肌明显破坏性的新陈代谢。促炎细胞因子主要通过增加蛋白酶分解和局部炎症所需的钙蛋白酶和E3连接酶以及Nf-κB的表达来发挥作用。促炎细胞因子还可以局部抑制IGF-1和胰岛素功能，从而增加FoxO激活并降低Akt功能（碳水化合物脂质和蛋白质代谢的中心点）。 结论：当前的进展表明骨骼肌萎缩过程中的肌肉质量损失是多因素的。尽管付出了巨大的努力，但市场上甚至没有一种FDA批准的药物。它表明促炎细胞因子之间的组织良好协调，需要进一步了解和探索。

关键词: 骨骼肌，促炎细胞因子，代谢，肌肉稳态，分子靶标，药物发现。

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