摘要
由致病细菌形成生物膜被认为是抵抗几种抗生素作用的最有力的机制/模式之一。生物膜在宿主，食物和设备等的表面上形成结构粘附物，并且通过其自身产生的某些化学物质进一步功能性地协调。这些化学物质被称为群体感应（QS）信号分子，并且参与种间，种内和交互作用水平的串扰，因此导致产生导致发病机理的毒力因子。细菌具有感知这些化学物质的受体，这些化学物质与进入的QS分子相互作用。随后是毒力分子的分泌，生物发光的调节，生物膜形成，抗生素抗性发展和运动行为反应。在自然环境中，不同的细菌物种（革兰氏阳性和革兰氏阴性）产生结构和功能不同的QS信号分子。最近和过去的研究表明，各种拮抗分子（天然和化学合成的）的特征在于通过阻断QS受体来抑制生物膜的形成和细菌毒力的减弱。这篇综述文章描述了结构，功能和生产水平上的各种QS受体。因此，通过用抑制性分子阻断这些受体可以是控制发病机理的潜在治疗方法。此外，这些受体还可以用作结构平台，借助生物信息学方法筛选最有效的抑制剂。
关键词: 细菌，抑制剂，发病机制，群体感应受体，生物膜，群体感应（QS）。
图形摘要
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