Advances in Antidiabetic Drugs Targeting Insulin Secretion

Title:Advances in Antidiabetic Drugs Targeting Insulin Secretion

Volume: 24 Issue: 34

Author(s): Yanting Ding, Yilian Li, Qin Chen*Bing Niu*

Affiliation:

• School of Life Sciences, Shanghai University, Shanghai 200444,China

• School of Life Sciences, Shanghai University, Shanghai 200444,China

Keywords: Diabetes mellitus, antidiabetic drugs, GLP-1R, KATP, GPR119, insulin.

Abstract: Background: Diabetes mellitus (DM) is a disease of systemic metabolic disorders caused by the decrease of secretion or sensitivity of insulin. In recent years, the study of insulin-related drug targets and the development of new drugs have become the popular topic of current medical research, and studies have shown that multiple signaling pathways are associated with diabetes treatment. At present, some new drugs based on the new target design have been listed on the market and have achieved good hypoglycemic effect. However, most of the drugs are still in the clinical or pre-clinical stage. The efficacy and safety of the drugs need further clinical validation.

Objective: This article will introduce the advancements of targets and drugs to promote insulin secretion.

Cite this article as:

Ding Yanting , Li Yilian , Chen Qin*, Niu Bing*, Advances in Antidiabetic Drugs Targeting Insulin Secretion, Current Pharmaceutical Design 2018; 24 (34) . https://dx.doi.org/10.2174/1381612824666181112113756