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General Review Article

花青素作为非传染性疾病中细胞氧化还原依赖性途径的调节剂

卷 27, 期 12, 2020

页: [1955 - 1996] 页: 42

弟呕挨: 10.2174/0929867325666181112093336

价格: $65

摘要

慢性非传染性疾病（NCD）主要表现为心血管疾病，糖尿病，慢性肺部疾病，癌症和几种慢性病理，是发病和死亡的主要原因之一，并且主要与代谢风险因素的发生有关。花青素（ACN）具有广泛的生物活性，例如抗炎，抗氧化剂，心脏保护和化学预防特性，能够促进人类健康。尽管乙腈具有明显的低生物利用度，但其代谢产物可能在观察到的体内保护作用中起重要作用。 本文直接涉及支持ACN可以保护人类免受几种NCD侵害的科学证据，这些NCD不仅可以充当抗氧化剂，还可以通过其调节细胞氧化还原依赖性信号传导的能力来发挥作用。特别是，ACN与NF-κB和AP-1信号转导途径相互作用，后者对氧化信号作出响应并介导促炎作用； Nrf2 / ARE途径及其受调节的细胞保护蛋白（GST，NQO，HO-1等） 。）参与细胞的抗氧化剂防御和有毒化合物的消除/灭活，因此可以抵抗化学/氧化应激条件引起的变化。此外，推测的串扰可能有助于解释ACN在不同病理状态下的保护作用，其特征是这些途径之间的平衡发生改变。因此，本综述强调了特定营养分子对人类健康的重要性，并着重于ACNs对抗各种疾病的分子靶标和潜在机制。

关键词: 花青素，慢性疾病，炎症，抗氧化剂，NF-κB，AP-1，Nrf2。

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