Abstract
The emergence of multidrug-resistant (MDR) pathogens and cancers alarms the world for the urgent exploration of new therapeutic drugs to treat the superbugs and cancer patients. Since the ancient time, natural products and/or their derivatives have become continuous sources of leading commercialized pharmacological compounds that are used as antibiotics and antitumor agents. An unexplored source of natural products, lichen, currently has evolved into a propitious source of diverse secondary metabolites with various bio-activities including anticancer and antimicrobial, offering the abundant potentiality for future drugs. Herein, we summarized the progress in the discovery of structurally diverse anticancer compounds (C1-C85) with their plausible mode of action and antimicrobial compounds (M1-M112) from lichen and lichen-derived fungi together with their biodiversity. This review covers natural products discussed in literature from January 1985 to December 2017.
Keywords: Lichen, anticancer and antimicrobial, biodiversity, diverse metabolites, secondary metabolites, lichenized fungi.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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