Abstract
Although some functional activities of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2 / IL-15 system demonstrate distinct roles of IL-15 for the activation of innate immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRγδ+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15 / IL-15R system.
Keywords: il-15, il-2, innate immunity, iel, il-15/il-15r
Current Molecular Medicine
Title: Critical Role for IL-15 in Innate Immunity
Volume: 2 Issue: 4
Author(s): Toshiaki Ohteki
Affiliation:
Keywords: il-15, il-2, innate immunity, iel, il-15/il-15r
Abstract: Although some functional activities of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2 / IL-15 system demonstrate distinct roles of IL-15 for the activation of innate immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRγδ+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15 / IL-15R system.
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Cite this article as:
Ohteki Toshiaki, Critical Role for IL-15 in Innate Immunity, Current Molecular Medicine 2002; 2 (4) . https://dx.doi.org/10.2174/1566524023362519
DOI https://dx.doi.org/10.2174/1566524023362519 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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