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Review Article

铂类抗癌化合物在联合治疗中的应用及给药的挑战

卷 27, 期 18, 2020

页: [3055 - 3078] 页: 24

弟呕挨: 10.2174/0929867325666181105115849

价格: $65

摘要

铂类药物是目前金属类药物中最重要的药物之一，广泛应用于实体恶性肿瘤的治疗。尽管铂的显著副作用和获得性耐药限制了其临床应用，但它对多种肿瘤均有较强的抑制作用。使用脂质体、树状大分子、聚合物、纳米管和其他纳米组合物等新兴技术的药物给药系统都显示出了安全给药铂基化合物的前景。由于纳米配方的特殊性;可在很大程度上避免不必要的副作用和耐药性。此外，联合治疗已被证明是提高铂类抗肿瘤药物疗效的有效途径。本文首先介绍了铂给药系统和联合治疗给药系统。然后，我们重点介绍了联合治疗给药领域的一些最新进展;特别是在利用以铂为基础的药物的细胞毒性、其他药物与铂的联合效应、评估药物靶向性、减少副作用和基于纳米技术的给药平台的位点特异性等方面的进展。

关键词: 给药，药物组合，铂类药物，纳米颗粒，抗肿瘤药物，纳米技术给药。

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