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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis of (R)-2-benzylmorpholine employing catalytic stereospecific rearrangement of L-Phenylalaninol

Author(s): Mandapati Bhargava Reddy and Ramasamy Anandhan*

Volume 16, Issue 8, 2019

Page: [633 - 636] Pages: 4

DOI: 10.2174/1570178615666181105110940

Price: $65

Abstract

An efficient synthesis of (R)-2-benzylmorpholine has been accomplished starting from L-phenylalaninol by employing stereospecific rearrangement of β-amino alcohol using catalytic amount of (CF3CO)2O as a key step.

Keywords: Morpholine, appetite suppressant agent, stereospecific rearrangement, debenzylation, alcohol, amine.

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